STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)    
Predicted Functional Partners:
CD1C
Ig-like domain-containing protein.
   
 0.996
BF2
Class I histocompatibility antigen, F10 alpha chain; Involved in the presentation of foreign antigens to the immune system.
   
0.993
BF1
MHC class I antigen alpha chain; Belongs to the MHC class I family.
   
0.993
CD8A-2
Ig-like domain-containing protein.
   
 
 0.976
TAPBP
Tapasin; Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
   
 0.974
PDIA3
Protein disulfide-isomerase A3; Belongs to the protein disulfide isomerase family.
   
 0.967
LOC768350
Ig-like domain-containing protein; Belongs to the MHC class I family.
   
0.959
RPA1
Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 
 0.949
MHCIA6
Ig-like domain-containing protein; Belongs to the MHC class I family.
   
0.935
WRN
Uncharacterized protein.
   
 
 0.914
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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