STRINGSTRING
KCNMA1 protein (Gallus gallus) - STRING interaction network
"KCNMA1" - Calcium-activated potassium channel subunit alpha-1 in Gallus gallus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KCNMA1Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...] (1113 aa)    
Predicted Functional Partners:
KCNMB1
Gallus gallus potassium large conductance calcium-activated channel, subfamily M, beta member 1 (KCNMB1), mRNA (200 aa)
       
  0.987
KCNMB4
Gallus gallus potassium large conductance calcium-activated channel, subfamily M, beta member 4 (KCNMB4), mRNA (211 aa)
     
 
  0.968
KCNMB2
Uncharacterized protein (266 aa)
     
 
  0.941
PRKACB
Protein kinase, cAMP-dependent, catalytic, beta (336 aa)
     
  0.878
PRKG1
Protein kinase, cGMP-dependent, type I (742 aa)
     
 
  0.852
ATP1B1
Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (248 aa)
     
 
  0.839
CTNNAL1
Catenin alpha like 1; Catenin (cadherin-associated protein), alpha-like 1 (763 aa)
     
 
  0.809
KCNN3
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (134 aa)
     
   
  0.715
CACNA1D
Voltage-dependent L-type calcium channel subunit alpha-1D; The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily (2126 aa)
     
 
  0.699
KCNH1
Uncharacterized protein; Potassium voltage-gated channel, subfamily H (eag-related), member 1 (899 aa)
     
   
  0.698
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (12%) [HD]