node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACE | AGT | ENSGALP00000039731 | ENSGALP00000018089 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | Angiotensinogen; Belongs to the serpin family. | 0.985 |
ACE | AGTR1 | ENSGALP00000039731 | ENSGALP00000057556 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. | 0.939 |
ACE | AGTR2 | ENSGALP00000039731 | ENSGALP00000067208 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. | 0.764 |
ACE | ALB | ENSGALP00000039731 | ENSGALP00000044604 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. | 0.740 |
ACE | ANPEP | ENSGALP00000039731 | ENSGALP00000044885 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | Aminopeptidase Ey; Broad specificity aminopeptidase. Degrades a variety of peptides possessing various N-terminal amino acids including hydrophobic, basic and acidic amino acids. Preferentially hydrolyzes small peptides consisting of 4 or 5 amino acids. Hydrolyzes the N- terminal Xaa-Pro bonds in the chicken brain peptide Leu-Pro-Leu-Arg- PheNH2, the substance P fragment Arg-Pro-Lys-Pro and the bradykinin fragment Arg-Pro-Pro-Gly-Phe. Hydrolyzes the N-formylated peptides fMet-Leu-Phe, fMet-Ala-Gly-Ser-Glu and fMet-Nle-Leu-Phe-Nle-Tyr-Lys, but does not hydrolyze peptides with acetylatio [...] | 0.779 |
ACE | COL3A1 | ENSGALP00000039731 | ENSGALP00000051057 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | 0.746 |
ACE | CTRB2 | ENSGALP00000039731 | ENSGALP00000000050 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.774 |
ACE | REN | ENSGALP00000039731 | ENSGALP00000000756 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | Renin; Belongs to the peptidase A1 family. | 0.981 |
ACE | TMEM27 | ENSGALP00000039731 | ENSGALP00000042770 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | Collectrin domain-containing protein. | 0.826 |
ACE | TMPRSS2 | ENSGALP00000039731 | ENSGALP00000025956 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | Transmembrane serine protease 2; Belongs to the peptidase S1 family. | 0.755 |
AGT | ACE | ENSGALP00000018089 | ENSGALP00000039731 | Angiotensinogen; Belongs to the serpin family. | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | 0.985 |
AGT | AGTR1 | ENSGALP00000018089 | ENSGALP00000057556 | Angiotensinogen; Belongs to the serpin family. | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. | 0.999 |
AGT | AGTR2 | ENSGALP00000018089 | ENSGALP00000067208 | Angiotensinogen; Belongs to the serpin family. | Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. | 0.996 |
AGT | ALB | ENSGALP00000018089 | ENSGALP00000044604 | Angiotensinogen; Belongs to the serpin family. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. | 0.511 |
AGT | REN | ENSGALP00000018089 | ENSGALP00000000756 | Angiotensinogen; Belongs to the serpin family. | Renin; Belongs to the peptidase A1 family. | 0.975 |
AGT | TMEM27 | ENSGALP00000018089 | ENSGALP00000042770 | Angiotensinogen; Belongs to the serpin family. | Collectrin domain-containing protein. | 0.695 |
AGTR1 | ACE | ENSGALP00000057556 | ENSGALP00000039731 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | 0.939 |
AGTR1 | AGT | ENSGALP00000057556 | ENSGALP00000018089 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. | Angiotensinogen; Belongs to the serpin family. | 0.999 |
AGTR1 | AGTR2 | ENSGALP00000057556 | ENSGALP00000067208 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. | Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. | 0.946 |
AGTR1 | REN | ENSGALP00000057556 | ENSGALP00000000756 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. | Renin; Belongs to the peptidase A1 family. | 0.846 |