STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SNCBBeta-synuclein; Belongs to the synuclein family. (272 aa)    
Predicted Functional Partners:
PSEN1
Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family.
      
 0.630
SCRN2
Secernin 2.
      
 0.626
ENSGALP00000070065
Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.
      
 0.618
SNCG
Gamma-synuclein; Belongs to the synuclein family.
   
 
0.608
CNDP1
Carnosine dipeptidase 1.
      
 0.607
TMEM263
Transmembrane protein 263.
      
 0.604
STMN4
Stathmin; Belongs to the stathmin family.
   
  
 0.578
SLC30A9
Solute carrier family 30 member 9.
      
 0.575
UNC5A
Unc-5 netrin receptor A.
   
  
 0.557
PANK3
Pantothenate kinase 3.
   
  
 0.553
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.