| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BACH2 | FOS | ENSGALP00000072471 | ENSGALP00000041340 | BTB domain and CNC homolog 2. | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity). | 0.432 |
| BACH2 | MAF | ENSGALP00000072471 | ENSGALP00000041121 | BTB domain and CNC homolog 2. | Transcription factor Maf; Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE). | 0.590 |
| COQ6 | DRD5 | ENSGALP00000016557 | ENSGALP00000036478 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. | 0.699 |
| COQ6 | KCTD15 | ENSGALP00000016557 | ENSGALP00000007835 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Potassium channel tetramerization domain containing 15. | 0.742 |
| COQ6 | MAF | ENSGALP00000016557 | ENSGALP00000041121 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Transcription factor Maf; Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE). | 0.564 |
| COQ6 | PCDH17 | ENSGALP00000016557 | ENSGALP00000027332 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Protocadherin 17. | 0.705 |
| DPM2 | MAF | ENSGALP00000008108 | ENSGALP00000041121 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. | Transcription factor Maf; Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE). | 0.569 |
| DRD5 | COQ6 | ENSGALP00000036478 | ENSGALP00000016557 | Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.699 |
| DRD5 | KCTD15 | ENSGALP00000036478 | ENSGALP00000007835 | Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. | Potassium channel tetramerization domain containing 15. | 0.699 |
| DRD5 | MAF | ENSGALP00000036478 | ENSGALP00000041121 | Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. | Transcription factor Maf; Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE). | 0.564 |
| DRD5 | PCDH17 | ENSGALP00000036478 | ENSGALP00000027332 | Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. | Protocadherin 17. | 0.627 |
| FOS | BACH2 | ENSGALP00000041340 | ENSGALP00000072471 | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity). | BTB domain and CNC homolog 2. | 0.432 |
| FOS | JUN | ENSGALP00000041340 | ENSGALP00000037247 | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity). | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. | 0.999 |
| FOS | MAF | ENSGALP00000041340 | ENSGALP00000041121 | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity). | Transcription factor Maf; Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE). | 0.606 |
| GGA1 | MAF | ENSGALP00000055669 | ENSGALP00000041121 | Golgi associated, gamma adaptin ear containing, ARF binding protein 1. | Transcription factor Maf; Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE). | 0.629 |
| JUN | FOS | ENSGALP00000037247 | ENSGALP00000041340 | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity). | 0.999 |
| JUN | MAF | ENSGALP00000037247 | ENSGALP00000041121 | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. | Transcription factor Maf; Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE). | 0.599 |
| KCTD15 | COQ6 | ENSGALP00000007835 | ENSGALP00000016557 | Potassium channel tetramerization domain containing 15. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.742 |
| KCTD15 | DRD5 | ENSGALP00000007835 | ENSGALP00000036478 | Potassium channel tetramerization domain containing 15. | Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. | 0.699 |
| KCTD15 | MAF | ENSGALP00000007835 | ENSGALP00000041121 | Potassium channel tetramerization domain containing 15. | Transcription factor Maf; Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE). | 0.564 |
