node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAM214A | HMG20B | ENSGALP00000050061 | ENSGALP00000041227 | Protein FAM214A; Belongs to the FAM214 family. | High mobility group 20B. | 0.729 |
FAM214A | LMBRD2 | ENSGALP00000050061 | ENSGALP00000021784 | Protein FAM214A; Belongs to the FAM214 family. | G-protein coupled receptor-associated protein LMBRD2; May associate with G-protein coupled receptors and regulate downstream signaling pathways; Belongs to the LIMR family. | 0.848 |
FAM214A | MEX3D | ENSGALP00000050061 | ENSGALP00000073308 | Protein FAM214A; Belongs to the FAM214 family. | Mex-3 RNA binding family member D. | 0.849 |
GSE1 | HMG20A | ENSGALP00000056128 | ENSGALP00000053537 | Gse1 coiled-coil protein. | High mobility group protein 20A; Plays a role in neuronal differentiation. | 0.726 |
GSE1 | HMG20B | ENSGALP00000056128 | ENSGALP00000041227 | Gse1 coiled-coil protein. | High mobility group 20B. | 0.796 |
GSE1 | KDM1A | ENSGALP00000056128 | ENSGALP00000048449 | Gse1 coiled-coil protein. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.536 |
GSE1 | RCOR1 | ENSGALP00000056128 | ENSGALP00000018546 | Gse1 coiled-coil protein. | REST corepressor 1. | 0.494 |
HDAC1 | HDAC2 | ENSGALP00000059784 | ENSGALP00000057637 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | 0.994 |
HDAC1 | HMG20A | ENSGALP00000059784 | ENSGALP00000053537 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. | High mobility group protein 20A; Plays a role in neuronal differentiation. | 0.411 |
HDAC1 | HMG20B | ENSGALP00000059784 | ENSGALP00000041227 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. | High mobility group 20B. | 0.713 |
HDAC1 | KDM1A | ENSGALP00000059784 | ENSGALP00000048449 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.898 |
HDAC1 | PHF21A | ENSGALP00000059784 | ENSGALP00000029877 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. | PHD-type domain-containing protein. | 0.696 |
HDAC1 | RCOR1 | ENSGALP00000059784 | ENSGALP00000018546 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. | REST corepressor 1. | 0.783 |
HDAC2 | HDAC1 | ENSGALP00000057637 | ENSGALP00000059784 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. | 0.994 |
HDAC2 | HMG20B | ENSGALP00000057637 | ENSGALP00000041227 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | High mobility group 20B. | 0.713 |
HDAC2 | KDM1A | ENSGALP00000057637 | ENSGALP00000048449 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.840 |
HDAC2 | PHF21A | ENSGALP00000057637 | ENSGALP00000029877 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | PHD-type domain-containing protein. | 0.696 |
HDAC2 | RCOR1 | ENSGALP00000057637 | ENSGALP00000018546 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | REST corepressor 1. | 0.783 |
HMG20A | GSE1 | ENSGALP00000053537 | ENSGALP00000056128 | High mobility group protein 20A; Plays a role in neuronal differentiation. | Gse1 coiled-coil protein. | 0.726 |
HMG20A | HDAC1 | ENSGALP00000053537 | ENSGALP00000059784 | High mobility group protein 20A; Plays a role in neuronal differentiation. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. | 0.411 |