THPO protein (Gallus gallus) - STRING interaction network

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Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

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[Homology]

Score

THPO

Thrombopoietin. (177 aa)

Predicted Functional Partners:

KITLG

0.866

CD34

0.768

IL6

0.609

CSF3

0.603

IL11

0.536

JAK2

0.530

IL7

0.450

ID3

0.414

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD34	CSF3	ENSGALP00000001784	ENSGALP00000044330	CD34 molecule.	Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily.	0.828
CD34	IL6	ENSGALP00000001784	ENSGALP00000068117	CD34 molecule.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.753
CD34	IL7	ENSGALP00000001784	ENSGALP00000052069	CD34 molecule.	Interleukin-7.	0.574
CD34	JAK2	ENSGALP00000001784	ENSGALP00000074116	CD34 molecule.	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...]	0.411
CD34	KITLG	ENSGALP00000001784	ENSGALP00000018246	CD34 molecule.	Processed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity).	0.878
CD34	THPO	ENSGALP00000001784	ENSGALP00000041285	CD34 molecule.	Thrombopoietin.	0.768
CSF3	CD34	ENSGALP00000044330	ENSGALP00000001784	Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily.	CD34 molecule.	0.828
CSF3	IL11	ENSGALP00000044330	ENSGALP00000066271	Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily.	Interleukin 11.	0.458
CSF3	IL6	ENSGALP00000044330	ENSGALP00000068117	Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.940
CSF3	IL7	ENSGALP00000044330	ENSGALP00000052069	Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily.	Interleukin-7.	0.810
CSF3	JAK2	ENSGALP00000044330	ENSGALP00000074116	Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily.	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...]	0.754
CSF3	KITLG	ENSGALP00000044330	ENSGALP00000018246	Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily.	Processed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity).	0.722
CSF3	THPO	ENSGALP00000044330	ENSGALP00000041285	Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily.	Thrombopoietin.	0.603
ID3	THPO	ENSGALP00000056330	ENSGALP00000041285	BHLH domain-containing protein.	Thrombopoietin.	0.414
IL11	CSF3	ENSGALP00000066271	ENSGALP00000044330	Interleukin 11.	Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily.	0.458
IL11	IL6	ENSGALP00000066271	ENSGALP00000068117	Interleukin 11.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.875
IL11	IL7	ENSGALP00000066271	ENSGALP00000052069	Interleukin 11.	Interleukin-7.	0.603
IL11	JAK2	ENSGALP00000066271	ENSGALP00000074116	Interleukin 11.	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...]	0.735
IL11	KITLG	ENSGALP00000066271	ENSGALP00000018246	Interleukin 11.	Processed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity).	0.588
IL11	THPO	ENSGALP00000066271	ENSGALP00000041285	Interleukin 11.	Thrombopoietin.	0.536