STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MT4Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals; Belongs to the metallothionein superfamily. Type 1 family. (63 aa)    
Predicted Functional Partners:
SLC30A7
Zinc transporter 7; Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis (By similarity). Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP.
      
 0.739
CP
Ceruloplasmin; Belongs to the multicopper oxidase family.
      
 0.718
ATP7A
ATPase copper transporting alpha.
      
 0.683
SLC30A5
Zinc transporter 5; Functions as a zinc transporter. Partly regulates cellular zinc homeostasis. Required with ZNT7 for activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
      
 0.669
ATOX1
HMA domain-containing protein.
   
  
 0.605
MT3
Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.
  
 
0.599
GPX1
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
   
  
 0.596
ATP7B
ATPase copper transporting beta.
   
  
 0.589
ALB
Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.
   
  
 0.588
GPX4
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
   
  
 0.582
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.