Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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ZFYVE27Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. (413 aa)    
Predicted Functional Partners:
VAPA
MSP domain-containing protein.
    
 
 0.920
REEP1
Receptor expression-enhancing protein.
    
 
 0.842
GPBP1L1
Uncharacterized protein.
   
  
 0.782
FYCO1
Uncharacterized protein.
      
 0.780
PDZD8
PDZ domain containing 8.
   
 
 0.767
ATL1
Atlastin GTPase 1.
    
 
 0.732
ATL2
Atlastin GTPase 2.
    
 
 0.731
VAPB
MSP domain-containing protein.
    
 
 0.726
STARD3
StAR related lipid transfer domain containing 3.
   
  
 0.723
REEP2
Receptor expression-enhancing protein.
    
 
 0.683
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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