YJU2 protein (Gallus gallus) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

YJU2

YJU2 splicing factor homolog. (421 aa)

Predicted Functional Partners:

DHX38

0.994

PLRG1

0.994

CDC5L

0.994

PRPF19

0.993

BUD31

0.992

CDC40

0.992

CRNKL1

0.991

SNW1

0.990

CWC25

0.985

PRPF8

0.983

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BUD31	CDC40	ENSGALP00000007481	ENSGALP00000024253	BUD31 homolog.	WD_REPEATS_REGION domain-containing protein.	0.995
BUD31	CDC5L	ENSGALP00000007481	ENSGALP00000065682	BUD31 homolog.	Cell division cycle 5 like.	0.994
BUD31	CRNKL1	ENSGALP00000007481	ENSGALP00000013717	BUD31 homolog.	Crooked neck pre-mRNA splicing factor 1.	0.996
BUD31	CWC25	ENSGALP00000007481	ENSGALP00000002477	BUD31 homolog.	CWC25 spliceosome associated protein homolog.	0.991
BUD31	DHX38	ENSGALP00000007481	ENSGALP00000037931	BUD31 homolog.	Uncharacterized protein.	0.992
BUD31	PLRG1	ENSGALP00000007481	ENSGALP00000059885	BUD31 homolog.	Pleiotropic regulator 1.	0.996
BUD31	PRPF19	ENSGALP00000007481	ENSGALP00000058486	BUD31 homolog.	Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity; Belongs to the WD repeat PRP19 family.	0.993
BUD31	PRPF8	ENSGALP00000007481	ENSGALP00000004641	BUD31 homolog.	Pre-mRNA processing factor 8.	0.993
BUD31	SNW1	ENSGALP00000007481	ENSGALP00000017080	BUD31 homolog.	SNW domain containing 1.	0.994
BUD31	YJU2	ENSGALP00000007481	ENSGALP00000044314	BUD31 homolog.	YJU2 splicing factor homolog.	0.992
CDC40	BUD31	ENSGALP00000024253	ENSGALP00000007481	WD_REPEATS_REGION domain-containing protein.	BUD31 homolog.	0.995
CDC40	CDC5L	ENSGALP00000024253	ENSGALP00000065682	WD_REPEATS_REGION domain-containing protein.	Cell division cycle 5 like.	0.995
CDC40	CRNKL1	ENSGALP00000024253	ENSGALP00000013717	WD_REPEATS_REGION domain-containing protein.	Crooked neck pre-mRNA splicing factor 1.	0.996
CDC40	CWC25	ENSGALP00000024253	ENSGALP00000002477	WD_REPEATS_REGION domain-containing protein.	CWC25 spliceosome associated protein homolog.	0.992
CDC40	DHX38	ENSGALP00000024253	ENSGALP00000037931	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.998
CDC40	PLRG1	ENSGALP00000024253	ENSGALP00000059885	WD_REPEATS_REGION domain-containing protein.	Pleiotropic regulator 1.	0.992
CDC40	PRPF19	ENSGALP00000024253	ENSGALP00000058486	WD_REPEATS_REGION domain-containing protein.	Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity; Belongs to the WD repeat PRP19 family.	0.992
CDC40	PRPF8	ENSGALP00000024253	ENSGALP00000004641	WD_REPEATS_REGION domain-containing protein.	Pre-mRNA processing factor 8.	0.991
CDC40	SNW1	ENSGALP00000024253	ENSGALP00000017080	WD_REPEATS_REGION domain-containing protein.	SNW domain containing 1.	0.994
CDC40	YJU2	ENSGALP00000024253	ENSGALP00000044314	WD_REPEATS_REGION domain-containing protein.	YJU2 splicing factor homolog.	0.992

page 1 of 6

Network Stats

number of nodes:

4

number of edges:

4

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.414

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060070

Canonical Wnt signaling pathway

3 of 81

1.9

0.9

0.0189

GO:0016055

Wnt signaling pathway

4 of 216

1.6

0.85

0.0185

GO:0090090

Negative regulation of canonical Wnt signaling pathway

3 of 98

1.82

0.83

0.0247

GO:0046849

Bone remodeling

2 of 14

2.49

0.83

0.0304

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071936

Coreceptor activity involved in Wnt signaling pathway

2 of 2

3.33

1.39

0.0031

GO:0039706

Co-receptor binding

2 of 7

2.79

1.12

0.0094

GO:0048019

Receptor antagonist activity

2 of 9

2.68

1.11

0.0095

GO:0042813

Wnt receptor activity

2 of 18

2.38

0.93

0.0197

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071821

FANCM-MHF complex

2 of 5

2.93

1.26

0.0052

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37339990

(2023) TGFbeta inhibition and mesenchymal to epithelial transition initiation by Xenopus egg extract: first steps towards early reprogramming in fish somatic cell.

3 of 42

2.19

1.18

0.0061

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21213

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

4 of 6

3.16

4.15

2.70e-08

CL:21106

Wnt signaling pathway, and Negative regulation of TCF-dependent signaling by WNT ligand antagonists

5 of 61

2.25

3.36

1.69e-07

CL:1161

Mixed, incl. Centromere complex assembly, and Carbohydrate-binding WSC

2 of 16

2.43

0.94

0.0190

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ola04310

Wnt signaling pathway

3 of 180

1.55

0.91

0.0120

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3772470

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

5 of 12

2.95

5.44

7.75e-11

MAP-201681

TCF dependent signaling in response to WNT

5 of 258

1.62

1.77

6.00e-05

MAP-195721

Signaling by WNT

5 of 413

1.41

1.33

0.00040

MAP-4641263

Regulation of FZD by ubiquitination

2 of 22

2.29

0.95

0.0180

MAP-162582

Signal Transduction

9 of 4038

0.68

0.53

0.0021

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990851

Wnt-Frizzled-LRP5/6 complex

2 of 2

3.33

1.53

0.0018

GOCC:0071821

FANCM-MHF complex

2 of 5

2.93

1.52

0.0018

GOCC:0098797

Plasma membrane protein complex

5 of 479

1.35

1.09

0.0018

GOCC:0098796

Membrane protein complex

6 of 1010

1.11

0.9

0.0018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01822

WSC domain

2 of 2

3.33

1.43

0.0027

PF04706

Dickkopf N-terminal cysteine-rich region

2 of 6

2.85

1.22

0.0063

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002889

Carbohydrate-binding WSC

3 of 3

3.33

2.75

1.08e-05

IPR039863

Dickkopf-like protein

2 of 6

2.85

0.94

0.0198

IPR006796

Dickkopf, N-terminal cysteine-rich

2 of 6

2.85

0.94

0.0198

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