STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT75IF rod domain-containing protein; Belongs to the intermediate filament family. (536 aa)    
Predicted Functional Partners:
LOC408038
Keratin.
   
  
 0.845
LOC431320
Keratin.
      
 0.749
TMEM79
Transmembrane protein 79.
      
 0.670
KRT13
IF rod domain-containing protein; Belongs to the intermediate filament family.
  
0.641
KRT12
Keratin 12; Belongs to the intermediate filament family.
  
0.633
KRT17
IF rod domain-containing protein; Belongs to the intermediate filament family.
  
0.629
KRT14
Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
  
0.615
SPTY2D1
Protein SPT2 homolog; Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro) (By similarity). Modulates RNA polymerase 1-mediated transcription. Required for optimal growth in the presence of the DNA damaging agents actinomycin D or mitomycin C (in vitro). Facilitates formation of tetrameric histone complexes c [...]
    
 
 0.612
LOC772080
IF rod domain-containing protein; Belongs to the intermediate filament family.
  
 
0.597
KRT40
IF rod domain-containing protein; Belongs to the intermediate filament family.
  
 
0.588
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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