PAPPA2 protein (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PAPPA2

Pappalysin 2. (1623 aa)

Predicted Functional Partners:

IGFBP5

0.747

TBXAS1

0.649

NUDT7

0.605

BLOC1S4

0.583

ADAMTSL2

0.576

IGFBP4

0.542

AMIGO1

0.540

CHST13

0.538

GDPD5

0.537

IGF2

0.531

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTSL2	GDPD5	ENSGALP00000056602	ENSGALP00000043850	ADAMTS like 2.	Glycerophosphodiester phosphodiesterase domain-containing protein 5; Glycerophosphodiester phosphodiesterase that promotes cell cycle exit and drives spinal motor neuron differentiation. Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane.	0.459
ADAMTSL2	PAPPA2	ENSGALP00000056602	ENSGALP00000045008	ADAMTS like 2.	Pappalysin 2.	0.576
ADAMTSL2	TBXAS1	ENSGALP00000056602	ENSGALP00000069343	ADAMTS like 2.	Thromboxane A synthase 1; Belongs to the cytochrome P450 family.	0.468
AMIGO1	PAPPA2	ENSGALP00000072821	ENSGALP00000045008	Adhesion molecule with Ig like domain 1.	Pappalysin 2.	0.540
BLOC1S4	PAPPA2	ENSGALP00000022076	ENSGALP00000045008	Biogenesis of lysosomal organelles complex 1 subunit 4.	Pappalysin 2.	0.583
CHST13	PAPPA2	ENSGALP00000056334	ENSGALP00000045008	Carbohydrate sulfotransferase.	Pappalysin 2.	0.538
GDPD5	ADAMTSL2	ENSGALP00000043850	ENSGALP00000056602	Glycerophosphodiester phosphodiesterase domain-containing protein 5; Glycerophosphodiester phosphodiesterase that promotes cell cycle exit and drives spinal motor neuron differentiation. Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane.	ADAMTS like 2.	0.459
GDPD5	NUDT7	ENSGALP00000043850	ENSGALP00000058479	Glycerophosphodiester phosphodiesterase domain-containing protein 5; Glycerophosphodiester phosphodiesterase that promotes cell cycle exit and drives spinal motor neuron differentiation. Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane.	Nudix hydrolase domain-containing protein.	0.456
GDPD5	PAPPA2	ENSGALP00000043850	ENSGALP00000045008	Glycerophosphodiester phosphodiesterase domain-containing protein 5; Glycerophosphodiester phosphodiesterase that promotes cell cycle exit and drives spinal motor neuron differentiation. Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane.	Pappalysin 2.	0.537
GDPD5	TBXAS1	ENSGALP00000043850	ENSGALP00000069343	Glycerophosphodiester phosphodiesterase domain-containing protein 5; Glycerophosphodiester phosphodiesterase that promotes cell cycle exit and drives spinal motor neuron differentiation. Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane.	Thromboxane A synthase 1; Belongs to the cytochrome P450 family.	0.478
IGF2	IGFBP4	ENSGALP00000048743	ENSGALP00000071448	Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling.	IGFBP N-terminal domain-containing protein.	0.840
IGF2	IGFBP5	ENSGALP00000048743	ENSGALP00000037370	Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling.	Insulin like growth factor binding protein 5.	0.876
IGF2	PAPPA2	ENSGALP00000048743	ENSGALP00000045008	Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling.	Pappalysin 2.	0.531
IGFBP4	IGF2	ENSGALP00000071448	ENSGALP00000048743	IGFBP N-terminal domain-containing protein.	Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling.	0.840
IGFBP4	PAPPA2	ENSGALP00000071448	ENSGALP00000045008	IGFBP N-terminal domain-containing protein.	Pappalysin 2.	0.542
IGFBP5	IGF2	ENSGALP00000037370	ENSGALP00000048743	Insulin like growth factor binding protein 5.	Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling.	0.876
IGFBP5	PAPPA2	ENSGALP00000037370	ENSGALP00000045008	Insulin like growth factor binding protein 5.	Pappalysin 2.	0.747
NUDT7	GDPD5	ENSGALP00000058479	ENSGALP00000043850	Nudix hydrolase domain-containing protein.	Glycerophosphodiester phosphodiesterase domain-containing protein 5; Glycerophosphodiester phosphodiesterase that promotes cell cycle exit and drives spinal motor neuron differentiation. Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane.	0.456
NUDT7	PAPPA2	ENSGALP00000058479	ENSGALP00000045008	Nudix hydrolase domain-containing protein.	Pappalysin 2.	0.605
PAPPA2	ADAMTSL2	ENSGALP00000045008	ENSGALP00000056602	Pappalysin 2.	ADAMTS like 2.	0.576