node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNMT1 | MBD4 | ENSGALP00000056402 | ENSGALP00000032601 | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. Mediates transcriptional repression by direct binding to HDAC2. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their [...] | Uncharacterized protein. | 0.708 |
DNMT1 | SUMO1 | ENSGALP00000056402 | ENSGALP00000069231 | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. Mediates transcriptional repression by direct binding to HDAC2. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their [...] | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as [...] | 0.500 |
DNMT1 | TDG | ENSGALP00000056402 | ENSGALP00000045187 | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. Mediates transcriptional repression by direct binding to HDAC2. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their [...] | UDG domain-containing protein. | 0.813 |
DNMT1 | TET1 | ENSGALP00000056402 | ENSGALP00000049715 | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. Mediates transcriptional repression by direct binding to HDAC2. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their [...] | Tet_JBP domain-containing protein. | 0.866 |
DNMT1 | TET3 | ENSGALP00000056402 | ENSGALP00000058639 | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. Mediates transcriptional repression by direct binding to HDAC2. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their [...] | Tet_JBP domain-containing protein. | 0.867 |
MBD4 | DNMT1 | ENSGALP00000032601 | ENSGALP00000056402 | Uncharacterized protein. | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. Mediates transcriptional repression by direct binding to HDAC2. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their [...] | 0.708 |
MBD4 | MUTYH | ENSGALP00000032601 | ENSGALP00000059297 | Uncharacterized protein. | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.574 |
MBD4 | SMUG1 | ENSGALP00000032601 | ENSGALP00000071202 | Uncharacterized protein. | Single-strand-selective monofunctional uracil-DNA glycosylase 1. | 0.885 |
MBD4 | TDG | ENSGALP00000032601 | ENSGALP00000045187 | Uncharacterized protein. | UDG domain-containing protein. | 0.886 |
MBD4 | TET3 | ENSGALP00000032601 | ENSGALP00000058639 | Uncharacterized protein. | Tet_JBP domain-containing protein. | 0.417 |
MUTYH | MBD4 | ENSGALP00000059297 | ENSGALP00000032601 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Uncharacterized protein. | 0.574 |
MUTYH | NTHL1 | ENSGALP00000059297 | ENSGALP00000008999 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.911 |
MUTYH | SMUG1 | ENSGALP00000059297 | ENSGALP00000071202 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Single-strand-selective monofunctional uracil-DNA glycosylase 1. | 0.730 |
MUTYH | TDG | ENSGALP00000059297 | ENSGALP00000045187 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | UDG domain-containing protein. | 0.791 |
MUTYH | UNG | ENSGALP00000059297 | ENSGALP00000033675 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.750 |
NTHL1 | MUTYH | ENSGALP00000008999 | ENSGALP00000059297 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.911 |
NTHL1 | SMUG1 | ENSGALP00000008999 | ENSGALP00000071202 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | Single-strand-selective monofunctional uracil-DNA glycosylase 1. | 0.451 |
NTHL1 | TDG | ENSGALP00000008999 | ENSGALP00000045187 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | UDG domain-containing protein. | 0.785 |
NTHL1 | UNG | ENSGALP00000008999 | ENSGALP00000033675 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.851 |
SMUG1 | MBD4 | ENSGALP00000071202 | ENSGALP00000032601 | Single-strand-selective monofunctional uracil-DNA glycosylase 1. | Uncharacterized protein. | 0.885 |