CUL5 protein (Gallus gallus) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

CUL5

Cullin 5; Belongs to the cullin family. (662 aa)

Predicted Functional Partners:

RBX1

0.999

RNF7

0.999

TCEB1

0.999

NEDD8

0.993

CISH

0.984

SOCS2

0.980

ARIH2

0.970

CBFB

0.967

WSB1

0.927

ASB2

0.898

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARIH2	CUL5	ENSGALP00000041807	ENSGALP00000045443	RBR-type E3 ubiquitin transferase.	Cullin 5; Belongs to the cullin family.	0.970
ARIH2	NEDD8	ENSGALP00000041807	ENSGALP00000055513	RBR-type E3 ubiquitin transferase.	NEDD8 ubiquitin like modifier.	0.777
ARIH2	RNF7	ENSGALP00000041807	ENSGALP00000033343	RBR-type E3 ubiquitin transferase.	RING-type domain-containing protein.	0.914
ARIH2	TCEB1	ENSGALP00000041807	ENSGALP00000055188	RBR-type E3 ubiquitin transferase.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.584
ASB2	CISH	ENSGALP00000017666	ENSGALP00000003536	Ankyrin repeat and SOCS box containing 2.	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	0.703
ASB2	CUL5	ENSGALP00000017666	ENSGALP00000045443	Ankyrin repeat and SOCS box containing 2.	Cullin 5; Belongs to the cullin family.	0.898
ASB2	NEDD8	ENSGALP00000017666	ENSGALP00000055513	Ankyrin repeat and SOCS box containing 2.	NEDD8 ubiquitin like modifier.	0.531
ASB2	RBX1	ENSGALP00000017666	ENSGALP00000019539	Ankyrin repeat and SOCS box containing 2.	RING-type domain-containing protein.	0.437
ASB2	RNF7	ENSGALP00000017666	ENSGALP00000033343	Ankyrin repeat and SOCS box containing 2.	RING-type domain-containing protein.	0.722
ASB2	SOCS2	ENSGALP00000017666	ENSGALP00000067577	Ankyrin repeat and SOCS box containing 2.	Uncharacterized protein.	0.446
ASB2	TCEB1	ENSGALP00000017666	ENSGALP00000055188	Ankyrin repeat and SOCS box containing 2.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.687
ASB2	WSB1	ENSGALP00000017666	ENSGALP00000009076	Ankyrin repeat and SOCS box containing 2.	SOCS box-containing WD protein SWiP-1.	0.501
CBFB	CUL5	ENSGALP00000005013	ENSGALP00000045443	Uncharacterized protein.	Cullin 5; Belongs to the cullin family.	0.967
CBFB	RNF7	ENSGALP00000005013	ENSGALP00000033343	Uncharacterized protein.	RING-type domain-containing protein.	0.853
CBFB	TCEB1	ENSGALP00000005013	ENSGALP00000055188	Uncharacterized protein.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.953
CISH	ASB2	ENSGALP00000003536	ENSGALP00000017666	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	Ankyrin repeat and SOCS box containing 2.	0.703
CISH	CUL5	ENSGALP00000003536	ENSGALP00000045443	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	Cullin 5; Belongs to the cullin family.	0.984
CISH	NEDD8	ENSGALP00000003536	ENSGALP00000055513	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	NEDD8 ubiquitin like modifier.	0.567
CISH	RBX1	ENSGALP00000003536	ENSGALP00000019539	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	RING-type domain-containing protein.	0.647
CISH	RNF7	ENSGALP00000003536	ENSGALP00000033343	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	RING-type domain-containing protein.	0.816