STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IFNAR2Uncharacterized protein. (524 aa)    
Predicted Functional Partners:
IFNAR1
Uncharacterized protein.
   
 0.999
IFNGR2
Uncharacterized protein.
  
 
 0.988
IFNGR1
Uncharacterized protein.
  
 
 0.978
IFNW1
Interferon type B; Has antiviral activities; Belongs to the alpha/beta interferon family.
     
 0.978
STAT1
Signal transducer and activator of transcription.
   
 0.971
TYK2
Tyrosine-protein kinase.
   
 0.965
JAK1
Tyrosine-protein kinase.
   
 0.963
IFNKL1
Uncharacterized protein.
    
 0.953
USP41
Ubiquitin carboxyl-terminal hydrolase.
   
 0.948
JAK2
Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...]
   
 0.945
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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