STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOPBP1DNA topoisomerase II binding protein 1. (1519 aa)    
Predicted Functional Partners:
CDC45
Cell division cycle 45.
   
 
 0.998
RAD9A
Rad9.
    
 0.998
BRCA1
Uncharacterized protein.
   
 0.995
BRIP1
Fanconi anemia group J protein homolog; DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the 'Fanconi anemia' pathway of DNA repair, after FANCD2 ubiquitination. Probably not involved in the repair of DNA double-strand breaks by homologous recombination; Belongs to the DEAD box helicase family. DEAH subfamily.
   
 0.995
TP53BP1
Tumor protein p53 binding protein 1.
    
 
 0.994
HUS1
Checkpoint protein; Belongs to the HUS1 family.
    
 0.991
TICRR
Treslin_N domain-containing protein.
   
 
 0.990
BARD1
Uncharacterized protein.
   
 0.987
ATRIP
Uncharacterized protein.
    
 0.984
ATR
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 0.980
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.