node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP13A2 | FBXO7 | ENSGALP00000052888 | ENSGALP00000020495 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | F-box domain-containing protein. | 0.865 |
ATP13A2 | PARK7 | ENSGALP00000052888 | ENSGALP00000048532 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] | 0.894 |
ATP13A2 | PINK1 | ENSGALP00000052888 | ENSGALP00000047654 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | PTEN induced kinase 1. | 0.874 |
ATP13A2 | PRKN | ENSGALP00000052888 | ENSGALP00000071728 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. | 0.767 |
ATP13A2 | SNCA | ENSGALP00000052888 | ENSGALP00000067652 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Alpha-synuclein; Belongs to the synuclein family. | 0.804 |
ATP13A2 | VPS35 | ENSGALP00000052888 | ENSGALP00000006965 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. | 0.880 |
BECN1 | FUNDC1 | ENSGALP00000004697 | ENSGALP00000043419 | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control; Belongs to the FUN14 family. | 0.519 |
BECN1 | MFN2 | ENSGALP00000004697 | ENSGALP00000007187 | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.575 |
BECN1 | PINK1 | ENSGALP00000004697 | ENSGALP00000047654 | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | PTEN induced kinase 1. | 0.876 |
BECN1 | PRKN | ENSGALP00000004697 | ENSGALP00000071728 | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. | 0.814 |
BECN1 | SNCA | ENSGALP00000004697 | ENSGALP00000067652 | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | Alpha-synuclein; Belongs to the synuclein family. | 0.488 |
BECN1 | VPS35 | ENSGALP00000004697 | ENSGALP00000006965 | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. | 0.684 |
FBXO7 | ATP13A2 | ENSGALP00000020495 | ENSGALP00000052888 | F-box domain-containing protein. | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.865 |
FBXO7 | PARK7 | ENSGALP00000020495 | ENSGALP00000048532 | F-box domain-containing protein. | Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] | 0.782 |
FBXO7 | PINK1 | ENSGALP00000020495 | ENSGALP00000047654 | F-box domain-containing protein. | PTEN induced kinase 1. | 0.900 |
FBXO7 | PRKN | ENSGALP00000020495 | ENSGALP00000071728 | F-box domain-containing protein. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. | 0.759 |
FBXO7 | SNCA | ENSGALP00000020495 | ENSGALP00000067652 | F-box domain-containing protein. | Alpha-synuclein; Belongs to the synuclein family. | 0.447 |
FBXO7 | VPS35 | ENSGALP00000020495 | ENSGALP00000006965 | F-box domain-containing protein. | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. | 0.804 |
FUNDC1 | BECN1 | ENSGALP00000043419 | ENSGALP00000004697 | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control; Belongs to the FUN14 family. | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | 0.519 |
FUNDC1 | MFN2 | ENSGALP00000043419 | ENSGALP00000007187 | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control; Belongs to the FUN14 family. | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.642 |