node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBFA2T2 | PRDM14 | ENSGALP00000004884 | ENSGALP00000048278 | Uncharacterized protein. | PR/SET domain 14. | 0.819 |
DAZL | DDX4 | ENSGALP00000018319 | ENSGALP00000023678 | Deleted in azoospermia-like; RNA-binding protein, which probably plays a central role in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts (By similarity); Belongs to the RRM DAZ family. | Uncharacterized protein; Belongs to the DEAD box helicase family. | 0.898 |
DAZL | LIN28A | ENSGALP00000018319 | ENSGALP00000056558 | Deleted in azoospermia-like; RNA-binding protein, which probably plays a central role in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts (By similarity); Belongs to the RRM DAZ family. | Protein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] | 0.579 |
DAZL | NPDC1 | ENSGALP00000018319 | ENSGALP00000070462 | Deleted in azoospermia-like; RNA-binding protein, which probably plays a central role in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts (By similarity); Belongs to the RRM DAZ family. | POU domain, class 5, transcription factor 3; Required for the maintenance of pluripotency and self-renewal of embryonic stem cells. Transcriptional activator that binds the DNA consensus sequence 5'-ATGCAAAT-3'; Belongs to the POU transcription factor family. | 0.850 |
DAZL | PRDM14 | ENSGALP00000018319 | ENSGALP00000048278 | Deleted in azoospermia-like; RNA-binding protein, which probably plays a central role in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts (By similarity); Belongs to the RRM DAZ family. | PR/SET domain 14. | 0.802 |
DAZL | TFAP2C | ENSGALP00000018319 | ENSGALP00000012451 | Deleted in azoospermia-like; RNA-binding protein, which probably plays a central role in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts (By similarity); Belongs to the RRM DAZ family. | Transcription factor AP-2 gamma. | 0.639 |
DDX4 | DAZL | ENSGALP00000023678 | ENSGALP00000018319 | Uncharacterized protein; Belongs to the DEAD box helicase family. | Deleted in azoospermia-like; RNA-binding protein, which probably plays a central role in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts (By similarity); Belongs to the RRM DAZ family. | 0.898 |
DDX4 | LIN28A | ENSGALP00000023678 | ENSGALP00000056558 | Uncharacterized protein; Belongs to the DEAD box helicase family. | Protein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] | 0.577 |
DDX4 | NPDC1 | ENSGALP00000023678 | ENSGALP00000070462 | Uncharacterized protein; Belongs to the DEAD box helicase family. | POU domain, class 5, transcription factor 3; Required for the maintenance of pluripotency and self-renewal of embryonic stem cells. Transcriptional activator that binds the DNA consensus sequence 5'-ATGCAAAT-3'; Belongs to the POU transcription factor family. | 0.718 |
DDX4 | PRDM14 | ENSGALP00000023678 | ENSGALP00000048278 | Uncharacterized protein; Belongs to the DEAD box helicase family. | PR/SET domain 14. | 0.664 |
ESRRB | LIN28A | ENSGALP00000044362 | ENSGALP00000056558 | Estrogen related receptor beta. | Protein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] | 0.491 |
ESRRB | NPDC1 | ENSGALP00000044362 | ENSGALP00000070462 | Estrogen related receptor beta. | POU domain, class 5, transcription factor 3; Required for the maintenance of pluripotency and self-renewal of embryonic stem cells. Transcriptional activator that binds the DNA consensus sequence 5'-ATGCAAAT-3'; Belongs to the POU transcription factor family. | 0.504 |
ESRRB | PRDM14 | ENSGALP00000044362 | ENSGALP00000048278 | Estrogen related receptor beta. | PR/SET domain 14. | 0.711 |
ESRRB | TFCP2L1 | ENSGALP00000044362 | ENSGALP00000028533 | Estrogen related receptor beta. | Transcription factor CP2 like 1. | 0.733 |
JUN | LEF1 | ENSGALP00000037247 | ENSGALP00000073992 | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. | HMG box domain-containing protein. | 0.407 |
JUN | PRDM14 | ENSGALP00000037247 | ENSGALP00000048278 | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. | PR/SET domain 14. | 0.603 |
LEF1 | JUN | ENSGALP00000073992 | ENSGALP00000037247 | HMG box domain-containing protein. | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. | 0.407 |
LEF1 | PRDM14 | ENSGALP00000073992 | ENSGALP00000048278 | HMG box domain-containing protein. | PR/SET domain 14. | 0.636 |
LIN28A | DAZL | ENSGALP00000056558 | ENSGALP00000018319 | Protein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] | Deleted in azoospermia-like; RNA-binding protein, which probably plays a central role in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts (By similarity); Belongs to the RRM DAZ family. | 0.579 |
LIN28A | DDX4 | ENSGALP00000056558 | ENSGALP00000023678 | Protein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] | Uncharacterized protein; Belongs to the DEAD box helicase family. | 0.577 |