STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAPLNPapilin, proteoglycan like sulfated glycoprotein. (863 aa)    
Predicted Functional Partners:
TFPI2
Tissue factor pathway inhibitor.
 
  
  
0.824
EPC1
Enhancer of polycomb homolog.
      
 0.703
MCF2L
Uncharacterized protein.
      
 0.675
ARID5B
AT-rich interactive domain-containing protein 5B; Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes (By similarity).
      
 0.637
FRAS1
Uncharacterized protein.
      
 0.625
TMEM97
Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
    
 
 0.608
OSBPL3
Oxysterol-binding protein; Belongs to the OSBP family.
      
 0.601
MTTPL
Microsomal triglyceride transfer protein large subunit-like protein.
      
 0.587
CERT1
Ceramide transporter 1.
      
 0.584
SPINK4
Serine peptidase inhibitor, Kazal type 4.
      
 0.583
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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