GSX2 protein (Gallus gallus) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

GSX2

GS homeobox 2. (263 aa)

Predicted Functional Partners:

ASCL1

0.756

TBR1

0.715

SP8

0.703

FOXG1

0.696

SCFD2

0.609

SP9

0.604

LHX6

0.602

TSHZ1

0.569

OLIG2

0.551

SHH

0.549

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	FOXG1	ENSGALP00000047577	ENSGALP00000054672	BHLH domain-containing protein.	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.	0.650
ASCL1	GSX2	ENSGALP00000047577	ENSGALP00000049767	BHLH domain-containing protein.	GS homeobox 2.	0.756
ASCL1	LHX6	ENSGALP00000047577	ENSGALP00000044370	BHLH domain-containing protein.	LIM homeobox 6.	0.558
ASCL1	OLIG2	ENSGALP00000047577	ENSGALP00000047462	BHLH domain-containing protein.	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord.	0.857
ASCL1	SHH	ENSGALP00000047577	ENSGALP00000010292	BHLH domain-containing protein.	Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.716
ASCL1	SP8	ENSGALP00000047577	ENSGALP00000046361	BHLH domain-containing protein.	Transcription factor Sp8; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos. Belongs to the Sp1 C2H2-type zinc-finger protein family.	0.463
ASCL1	SP9	ENSGALP00000047577	ENSGALP00000044053	BHLH domain-containing protein.	Sp9 transcription factor.	0.478
ASCL1	TBR1	ENSGALP00000047577	ENSGALP00000048357	BHLH domain-containing protein.	T-box brain transcription factor 1.	0.576
FOXG1	ASCL1	ENSGALP00000054672	ENSGALP00000047577	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.	BHLH domain-containing protein.	0.650
FOXG1	GSX2	ENSGALP00000054672	ENSGALP00000049767	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.	GS homeobox 2.	0.696
FOXG1	LHX6	ENSGALP00000054672	ENSGALP00000044370	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.	LIM homeobox 6.	0.660
FOXG1	OLIG2	ENSGALP00000054672	ENSGALP00000047462	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord.	0.491
FOXG1	SHH	ENSGALP00000054672	ENSGALP00000010292	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.	Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.727
FOXG1	TBR1	ENSGALP00000054672	ENSGALP00000048357	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.	T-box brain transcription factor 1.	0.865
GSX2	ASCL1	ENSGALP00000049767	ENSGALP00000047577	GS homeobox 2.	BHLH domain-containing protein.	0.756
GSX2	FOXG1	ENSGALP00000049767	ENSGALP00000054672	GS homeobox 2.	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.	0.696
GSX2	LHX6	ENSGALP00000049767	ENSGALP00000044370	GS homeobox 2.	LIM homeobox 6.	0.602
GSX2	OLIG2	ENSGALP00000049767	ENSGALP00000047462	GS homeobox 2.	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord.	0.551
GSX2	SCFD2	ENSGALP00000049767	ENSGALP00000045611	GS homeobox 2.	Sec1 family domain containing 2; Belongs to the STXBP/unc-18/SEC1 family.	0.609
GSX2	SHH	ENSGALP00000049767	ENSGALP00000010292	GS homeobox 2.	Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.549