node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALYREF | METTL16 | ENSGALP00000011696 | ENSGALP00000023989 | RRM domain-containing protein. | RNA N6-adenosine-methyltransferase METTL16; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S- adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2 [...] | 0.501 |
ALYREF | METTL4 | ENSGALP00000011696 | ENSGALP00000053906 | RRM domain-containing protein. | Methyltransferase like 4; Belongs to the MT-A70-like family. | 0.567 |
ALYREF | RSRP1 | ENSGALP00000011696 | ENSGALP00000051118 | RRM domain-containing protein. | Arginine and serine rich protein 1. | 0.631 |
EFCAB7 | ENTPD4 | ENSGALP00000017888 | ENSGALP00000000530 | EF-hand calcium binding domain 7. | Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. | 0.840 |
EFCAB7 | RSRP1 | ENSGALP00000017888 | ENSGALP00000051118 | EF-hand calcium binding domain 7. | Arginine and serine rich protein 1. | 0.600 |
ENTPD4 | EFCAB7 | ENSGALP00000000530 | ENSGALP00000017888 | Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. | EF-hand calcium binding domain 7. | 0.840 |
ENTPD4 | RSRP1 | ENSGALP00000000530 | ENSGALP00000051118 | Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. | Arginine and serine rich protein 1. | 0.533 |
KDM1A | KDM4B | ENSGALP00000048449 | ENSGALP00000065163 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Lysine demethylase 4B. | 0.693 |
KDM1A | METTL4 | ENSGALP00000048449 | ENSGALP00000053906 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Methyltransferase like 4; Belongs to the MT-A70-like family. | 0.577 |
KDM1A | RSRP1 | ENSGALP00000048449 | ENSGALP00000051118 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Arginine and serine rich protein 1. | 0.581 |
KDM4B | KDM1A | ENSGALP00000065163 | ENSGALP00000048449 | Lysine demethylase 4B. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.693 |
KDM4B | METTL16 | ENSGALP00000065163 | ENSGALP00000023989 | Lysine demethylase 4B. | RNA N6-adenosine-methyltransferase METTL16; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S- adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2 [...] | 0.430 |
KDM4B | METTL4 | ENSGALP00000065163 | ENSGALP00000053906 | Lysine demethylase 4B. | Methyltransferase like 4; Belongs to the MT-A70-like family. | 0.443 |
KDM4B | RSRP1 | ENSGALP00000065163 | ENSGALP00000051118 | Lysine demethylase 4B. | Arginine and serine rich protein 1. | 0.601 |
METTL16 | ALYREF | ENSGALP00000023989 | ENSGALP00000011696 | RNA N6-adenosine-methyltransferase METTL16; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S- adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2 [...] | RRM domain-containing protein. | 0.501 |
METTL16 | KDM4B | ENSGALP00000023989 | ENSGALP00000065163 | RNA N6-adenosine-methyltransferase METTL16; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S- adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2 [...] | Lysine demethylase 4B. | 0.430 |
METTL16 | METTL3 | ENSGALP00000023989 | ENSGALP00000058993 | RNA N6-adenosine-methyltransferase METTL16; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S- adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2 [...] | Methyltransferase like 3; Belongs to the MT-A70-like family. | 0.785 |
METTL16 | METTL4 | ENSGALP00000023989 | ENSGALP00000053906 | RNA N6-adenosine-methyltransferase METTL16; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S- adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2 [...] | Methyltransferase like 4; Belongs to the MT-A70-like family. | 0.826 |
METTL16 | PRDM5 | ENSGALP00000023989 | ENSGALP00000019484 | RNA N6-adenosine-methyltransferase METTL16; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S- adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2 [...] | PR/SET domain 5. | 0.477 |
METTL16 | RSRP1 | ENSGALP00000023989 | ENSGALP00000051118 | RNA N6-adenosine-methyltransferase METTL16; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S- adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2 [...] | Arginine and serine rich protein 1. | 0.748 |