STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
POU6F2Uncharacterized protein. (166 aa)    
Predicted Functional Partners:
PKDCCB
PIP49_C domain-containing protein.
   
  
 0.672
LRIT1
Leucine rich repeat, Ig-like and transmembrane domains 1.
    
 
 0.600
IRX2
Homeobox domain-containing protein.
      
 0.588
POU4F2
POU domain protein.
   
 
 0.569
CTDP1
CTD phosphatase subunit 1.
      
 0.525
IRX1
Homeobox domain-containing protein.
      
 0.514
TTC29
Tetratricopeptide repeat domain 29.
   
  
 0.484
GXYLT2
Glucoside xylosyltransferase 2.
      
 0.483
POU4F3-2
Brain-specific homeobox/POU domain protein 3; May play a role in specifying terminally differentiated neuronal phenotypes; Belongs to the POU transcription factor family. Class-4 subfamily.
   
 
 0.458
POU4F1
POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...]
   
 
 0.457
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.