node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AURKA | CCNA1 | ENSGALP00000032883 | ENSGALP00000027497 | Aurora kinase A; Belongs to the protein kinase superfamily. | Cyclin A1; Belongs to the cyclin family. | 0.735 |
AURKA | CCNA2 | ENSGALP00000032883 | ENSGALP00000019361 | Aurora kinase A; Belongs to the protein kinase superfamily. | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | 0.853 |
AURKA | CCNB1 | ENSGALP00000032883 | ENSGALP00000006605 | Aurora kinase A; Belongs to the protein kinase superfamily. | G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition. | 0.927 |
AURKA | CCNB3 | ENSGALP00000032883 | ENSGALP00000059571 | Aurora kinase A; Belongs to the protein kinase superfamily. | G2/mitotic-specific cyclin-B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Could be involved at the G2/M (mitosis or meiosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. | 0.711 |
AURKA | CDC20 | ENSGALP00000032883 | ENSGALP00000016189 | Aurora kinase A; Belongs to the protein kinase superfamily. | WD_REPEATS_REGION domain-containing protein. | 0.932 |
AURKA | CDK1 | ENSGALP00000032883 | ENSGALP00000004867 | Aurora kinase A; Belongs to the protein kinase superfamily. | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.927 |
AURKA | CKS2 | ENSGALP00000032883 | ENSGALP00000051853 | Aurora kinase A; Belongs to the protein kinase superfamily. | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. | 0.746 |
AURKA | SKP1 | ENSGALP00000032883 | ENSGALP00000010447 | Aurora kinase A; Belongs to the protein kinase superfamily. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). | 0.637 |
AURKA | SKP2 | ENSGALP00000032883 | ENSGALP00000005599 | Aurora kinase A; Belongs to the protein kinase superfamily. | F-box domain-containing protein. | 0.419 |
AURKA | WDR41 | ENSGALP00000032883 | ENSGALP00000006929 | Aurora kinase A; Belongs to the protein kinase superfamily. | WD repeat domain 41. | 0.602 |
CCNA1 | AURKA | ENSGALP00000027497 | ENSGALP00000032883 | Cyclin A1; Belongs to the cyclin family. | Aurora kinase A; Belongs to the protein kinase superfamily. | 0.735 |
CCNA1 | CCNA2 | ENSGALP00000027497 | ENSGALP00000019361 | Cyclin A1; Belongs to the cyclin family. | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | 0.936 |
CCNA1 | CCNB1 | ENSGALP00000027497 | ENSGALP00000006605 | Cyclin A1; Belongs to the cyclin family. | G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition. | 0.785 |
CCNA1 | CCNB3 | ENSGALP00000027497 | ENSGALP00000059571 | Cyclin A1; Belongs to the cyclin family. | G2/mitotic-specific cyclin-B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Could be involved at the G2/M (mitosis or meiosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. | 0.679 |
CCNA1 | CDC20 | ENSGALP00000027497 | ENSGALP00000016189 | Cyclin A1; Belongs to the cyclin family. | WD_REPEATS_REGION domain-containing protein. | 0.959 |
CCNA1 | CDK1 | ENSGALP00000027497 | ENSGALP00000004867 | Cyclin A1; Belongs to the cyclin family. | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.998 |
CCNA1 | CKS2 | ENSGALP00000027497 | ENSGALP00000051853 | Cyclin A1; Belongs to the cyclin family. | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. | 0.748 |
CCNA1 | SKP1 | ENSGALP00000027497 | ENSGALP00000010447 | Cyclin A1; Belongs to the cyclin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). | 0.930 |
CCNA1 | SKP2 | ENSGALP00000027497 | ENSGALP00000005599 | Cyclin A1; Belongs to the cyclin family. | F-box domain-containing protein. | 0.983 |
CCNA1 | WDR41 | ENSGALP00000027497 | ENSGALP00000006929 | Cyclin A1; Belongs to the cyclin family. | WD repeat domain 41. | 0.647 |