PTGS1 protein (Gallus gallus) - STRING interaction network

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Score

PTGS1

Prostaglandin-endoperoxide synthase 1. (607 aa)

Predicted Functional Partners:

PTGES2

0.956

PTGES

0.946

TBXAS1

0.944

PTGES3

0.941

HPGDS

0.931

PTGDS

0.927

PTGS2

0.925

ALOX5

0.919

RP11-400G3.5

0.915

CYP2C18

0.902

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALOX5	CYP2C18	ENSGALP00000009402	ENSGALP00000008773	Arachidonate 5-lipoxygenase.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.983
ALOX5	PTGS1	ENSGALP00000009402	ENSGALP00000053876	Arachidonate 5-lipoxygenase.	Prostaglandin-endoperoxide synthase 1.	0.919
ALOX5	PTGS2	ENSGALP00000009402	ENSGALP00000054566	Arachidonate 5-lipoxygenase.	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...]	0.919
ALOX5	RP11-400G3.5	ENSGALP00000009402	ENSGALP00000053419	Arachidonate 5-lipoxygenase.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.902
CYP2C18	ALOX5	ENSGALP00000008773	ENSGALP00000009402	Uncharacterized protein; Belongs to the cytochrome P450 family.	Arachidonate 5-lipoxygenase.	0.983
CYP2C18	PTGS1	ENSGALP00000008773	ENSGALP00000053876	Uncharacterized protein; Belongs to the cytochrome P450 family.	Prostaglandin-endoperoxide synthase 1.	0.902
CYP2C18	PTGS2	ENSGALP00000008773	ENSGALP00000054566	Uncharacterized protein; Belongs to the cytochrome P450 family.	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...]	0.900
CYP2C18	RP11-400G3.5	ENSGALP00000008773	ENSGALP00000053419	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.900
HPGDS	PTGDS	ENSGALP00000016919	ENSGALP00000052720	Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide.	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	0.972
HPGDS	PTGES	ENSGALP00000016919	ENSGALP00000073272	Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide.	Prostaglandin E synthase.	0.935
HPGDS	PTGES2	ENSGALP00000016919	ENSGALP00000051084	Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide.	Prostaglandin E synthase 2; Belongs to the GST superfamily.	0.931
HPGDS	PTGES3	ENSGALP00000016919	ENSGALP00000069892	Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide.	Prostaglandin E synthase 3; Molecular chaperone.	0.942
HPGDS	PTGS1	ENSGALP00000016919	ENSGALP00000053876	Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide.	Prostaglandin-endoperoxide synthase 1.	0.931
HPGDS	PTGS2	ENSGALP00000016919	ENSGALP00000054566	Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide.	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...]	0.930
HPGDS	TBXAS1	ENSGALP00000016919	ENSGALP00000069343	Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide.	Thromboxane A synthase 1; Belongs to the cytochrome P450 family.	0.933
PTGDS	HPGDS	ENSGALP00000052720	ENSGALP00000016919	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide.	0.972
PTGDS	PTGES	ENSGALP00000052720	ENSGALP00000073272	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	Prostaglandin E synthase.	0.931
PTGDS	PTGES2	ENSGALP00000052720	ENSGALP00000051084	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	Prostaglandin E synthase 2; Belongs to the GST superfamily.	0.930
PTGDS	PTGES3	ENSGALP00000052720	ENSGALP00000069892	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	Prostaglandin E synthase 3; Molecular chaperone.	0.951
PTGDS	PTGS1	ENSGALP00000052720	ENSGALP00000053876	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	Prostaglandin-endoperoxide synthase 1.	0.927