STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DCP1ADecapping mRNA 1A. (582 aa)    
Predicted Functional Partners:
DCP2
Decapping mRNA 2.
    
 0.998
XRN1
5'-3' exoribonuclease 1.
   
 0.995
PNRC2
Proline-rich nuclear receptor coactivator 2; Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity); Belongs to the PNRC family. PNRC2 subfamily.
    
 
 0.982
EDC3
Enhancer of mRNA-decapping protein 3; Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity).
   
 
 0.972
DCP1B
Decapping mRNA 1B.
  
 
0.965
DDX6
Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, may play a role in mRNA decapping; Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
   
 
 0.961
EDC4
Enhancer of mRNA decapping 4.
   
 
 0.925
PATL1
PAT1 homolog 1, processing body mRNA decay factor.
    
 
 0.860
TIA1
TIA-1.
   
 
 0.854
UPF1
UPF1 RNA helicase and ATPase.
    
 
 0.847
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.