STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC48A1Heme transporter HRG1; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. Belongs to the HRG family. (147 aa)    
Predicted Functional Partners:
LARP4
HTH La-type RNA-binding domain-containing protein.
      
 0.844
TWIST3
Twist3.
      
 0.763
RPAP3
RNA polymerase II-associated protein 3; May for an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein.
      
 0.741
TMEM106C
Transmembrane protein 106C.
      
 0.707
ZNF410
Uncharacterized protein.
      
 0.706
HDAC7
Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
      
 0.600
ASIC1
Acid-sensing ion channel 1; Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily.
      
 0.589
RAPGEF3
Rap guanine nucleotide exchange factor 3.
      
 0.588
SLC46A1
Uncharacterized protein.
      
 0.536
GGA2
Uncharacterized protein.
      
 0.478
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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