MTDH protein (Gallus gallus) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

MTDH

Uncharacterized protein. (383 aa)

Predicted Functional Partners:

MTDH-2

0.955

ZC3H8

0.702

UBE3A

0.630

SLC4A1AP

0.587

PGP

0.544

MRPL28

0.537

DIDO1

0.533

CPQ

0.528

DCUN1D1

0.519

MAP3K2

0.519

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPQ	MTDH	ENSGALP00000070354	ENSGALP00000055382	Peptidase_M28 domain-containing protein.	Uncharacterized protein.	0.528
DCUN1D1	MTDH	ENSGALP00000014300	ENSGALP00000055382	DCN1-like protein 1; Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates.	Uncharacterized protein.	0.519
DCUN1D1	MTDH-2	ENSGALP00000014300	ENSGALP00000052845	DCN1-like protein 1; Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates.	Uncharacterized protein.	0.536
DCUN1D1	PGP	ENSGALP00000014300	ENSGALP00000009453	DCN1-like protein 1; Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates.	Glycerol-3-phosphate phosphatase; Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP.	0.708
DIDO1	MTDH	ENSGALP00000059997	ENSGALP00000055382	Death inducer-obliterator 1.	Uncharacterized protein.	0.533
DIDO1	MTDH-2	ENSGALP00000059997	ENSGALP00000052845	Death inducer-obliterator 1.	Uncharacterized protein.	0.582
DIDO1	SLC4A1AP	ENSGALP00000059997	ENSGALP00000037475	Death inducer-obliterator 1.	Solute carrier family 4 member 1 adaptor protein.	0.733
DIDO1	ZC3H8	ENSGALP00000059997	ENSGALP00000013443	Death inducer-obliterator 1.	Uncharacterized protein.	0.797
MAP3K2	MTDH	ENSGALP00000018719	ENSGALP00000055382	Protein kinase domain-containing protein.	Uncharacterized protein.	0.519
MAP3K2	MTDH-2	ENSGALP00000018719	ENSGALP00000052845	Protein kinase domain-containing protein.	Uncharacterized protein.	0.537
MRPL28	MTDH	ENSGALP00000021919	ENSGALP00000055382	Uncharacterized protein.	Uncharacterized protein.	0.537
MTDH	CPQ	ENSGALP00000055382	ENSGALP00000070354	Uncharacterized protein.	Peptidase_M28 domain-containing protein.	0.528
MTDH	DCUN1D1	ENSGALP00000055382	ENSGALP00000014300	Uncharacterized protein.	DCN1-like protein 1; Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates.	0.519
MTDH	DIDO1	ENSGALP00000055382	ENSGALP00000059997	Uncharacterized protein.	Death inducer-obliterator 1.	0.533
MTDH	MAP3K2	ENSGALP00000055382	ENSGALP00000018719	Uncharacterized protein.	Protein kinase domain-containing protein.	0.519
MTDH	MRPL28	ENSGALP00000055382	ENSGALP00000021919	Uncharacterized protein.	Uncharacterized protein.	0.537
MTDH	MTDH-2	ENSGALP00000055382	ENSGALP00000052845	Uncharacterized protein.	Uncharacterized protein.	0.955
MTDH	PGP	ENSGALP00000055382	ENSGALP00000009453	Uncharacterized protein.	Glycerol-3-phosphate phosphatase; Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP.	0.544
MTDH	SLC4A1AP	ENSGALP00000055382	ENSGALP00000037475	Uncharacterized protein.	Solute carrier family 4 member 1 adaptor protein.	0.587
MTDH	UBE3A	ENSGALP00000055382	ENSGALP00000065010	Uncharacterized protein.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.630