STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NEDD8NEDD8 ubiquitin like modifier. (85 aa)    
Predicted Functional Partners:
NAE1
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M (By similarity).
   
 0.999
UBA3
Ubiquitin like modifier activating enzyme 3.
   
 0.999
UBE2M
Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.999
CUL1
Cullin 1; Belongs to the cullin family.
    
 0.998
RBX1
RING-type domain-containing protein.
   
 0.995
SENP8
ULP_PROTEASE domain-containing protein.
    
 0.995
UBE2F
NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
   
 0.994
CUL5
Cullin 5; Belongs to the cullin family.
    
 0.993
CUL2
CULLIN_2 domain-containing protein; Belongs to the cullin family.
    
 0.989
CUL3
Cullin 3; Belongs to the cullin family.
    
 0.985
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.