LAPTM5 protein (Gallus gallus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

LAPTM5

Lysosomal protein transmembrane 5. (256 aa)

Predicted Functional Partners:

LAPTM4B

0.910

LAPTM4A

0.906

NOL10

0.765

SERINC2

0.760

WDFY4

0.695

RAB39A

0.669

C1QA

0.609

CNNM4

0.602

KIAA0513

0.601

CSF1R

0.584

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1QA	CSF1R	ENSGALP00000007596	ENSGALP00000009176	Complement C1q A chain.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.857
C1QA	LAPTM5	ENSGALP00000007596	ENSGALP00000055692	Complement C1q A chain.	Lysosomal protein transmembrane 5.	0.609
CNNM4	LAPTM5	ENSGALP00000071183	ENSGALP00000055692	Cyclin and CBS domain divalent metal cation transport mediator 4.	Lysosomal protein transmembrane 5.	0.602
CSF1R	C1QA	ENSGALP00000009176	ENSGALP00000007596	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Complement C1q A chain.	0.857
CSF1R	LAPTM5	ENSGALP00000009176	ENSGALP00000055692	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Lysosomal protein transmembrane 5.	0.584
KIAA0513	LAPTM5	ENSGALP00000047119	ENSGALP00000055692	KIAA0513.	Lysosomal protein transmembrane 5.	0.601
KIAA0513	NOL10	ENSGALP00000047119	ENSGALP00000026477	KIAA0513.	Nucleolar protein 10.	0.950
KIAA0513	RAB39A	ENSGALP00000047119	ENSGALP00000027673	KIAA0513.	RAB39A, member RAS oncogene family.	0.843
LAPTM4A	LAPTM4B	ENSGALP00000026537	ENSGALP00000046014	Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.	Lysosomal protein transmembrane 4 beta.	0.903
LAPTM4A	LAPTM5	ENSGALP00000026537	ENSGALP00000055692	Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.	Lysosomal protein transmembrane 5.	0.906
LAPTM4B	LAPTM4A	ENSGALP00000046014	ENSGALP00000026537	Lysosomal protein transmembrane 4 beta.	Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.	0.903
LAPTM4B	LAPTM5	ENSGALP00000046014	ENSGALP00000055692	Lysosomal protein transmembrane 4 beta.	Lysosomal protein transmembrane 5.	0.910
LAPTM5	C1QA	ENSGALP00000055692	ENSGALP00000007596	Lysosomal protein transmembrane 5.	Complement C1q A chain.	0.609
LAPTM5	CNNM4	ENSGALP00000055692	ENSGALP00000071183	Lysosomal protein transmembrane 5.	Cyclin and CBS domain divalent metal cation transport mediator 4.	0.602
LAPTM5	CSF1R	ENSGALP00000055692	ENSGALP00000009176	Lysosomal protein transmembrane 5.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.584
LAPTM5	KIAA0513	ENSGALP00000055692	ENSGALP00000047119	Lysosomal protein transmembrane 5.	KIAA0513.	0.601
LAPTM5	LAPTM4A	ENSGALP00000055692	ENSGALP00000026537	Lysosomal protein transmembrane 5.	Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.	0.906
LAPTM5	LAPTM4B	ENSGALP00000055692	ENSGALP00000046014	Lysosomal protein transmembrane 5.	Lysosomal protein transmembrane 4 beta.	0.910
LAPTM5	NOL10	ENSGALP00000055692	ENSGALP00000026477	Lysosomal protein transmembrane 5.	Nucleolar protein 10.	0.765
LAPTM5	RAB39A	ENSGALP00000055692	ENSGALP00000027673	Lysosomal protein transmembrane 5.	RAB39A, member RAS oncogene family.	0.669

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Network Stats

number of nodes:

11

number of edges:

15

average node degree:

2.73

avg. local clustering coefficient:

0.859

expected number of edges:

10

PPI enrichment p-value:

0.105

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032957

Inositol trisphosphate metabolic process

4 of 5

3.24

4.19

2.40e-08

GO:0070266

Necroptotic process

4 of 13

2.83

3.59

2.27e-07

GO:0006066

Alcohol metabolic process

5 of 291

1.58

1.61

0.00014

GO:0052746

Inositol phosphorylation

2 of 3

3.16

1.54

0.0017

GO:0032958

Inositol phosphate biosynthetic process

2 of 14

2.5

0.97

0.0167

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000825

Inositol tetrakisphosphate 6-kinase activity

4 of 4

3.34

4.61

4.39e-09

GO:0051766

Inositol trisphosphate kinase activity

4 of 9

2.99

4.26

1.49e-08

GO:0003993

Acid phosphatase activity

3 of 7

2.97

2.88

5.66e-06

GO:0102732

myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity

2 of 2

3.34

1.83

0.00051

GO:0052726

inositol-1,3,4-trisphosphate 5-kinase activity

2 of 2

3.34

1.83

0.00051

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:30075

Acid phosphatase activity, and Alkaline phosphatase activity

6 of 14

2.97

6.68

3.23e-13

CL:30076

Acid phosphatase activity, and Phosphodiesterase I activity

4 of 7

3.1

4.32

1.27e-08

CL:38050

Inositol trisphosphate kinase activity, and Inositol tetrakisphosphate phosphatase activity

4 of 17

2.71

3.62

1.72e-07

CL:38074

Inositol phosphorylation, and Inositol tetrakisphosphate 5-kinase activity

3 of 5

3.12

2.98

3.89e-06

CL:30089

Alkaline phosphatase activity, and Acid phosphatase activity

2 of 7

2.8

1.41

0.0028

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00730

Thiamine metabolism

4 of 21

2.62

3.84

5.24e-08

map00740

Riboflavin metabolism

3 of 19

2.54

2.8

5.30e-06

map00562

Inositol phosphate metabolism

5 of 169

1.81

2.66

5.39e-07

map04070

Phosphatidylinositol signaling system

4 of 181

1.68

1.89

4.16e-05

map01100

Metabolic pathways

11 of 3242

0.87

0.96

5.24e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483249

Inositol phosphate metabolism

5 of 70

2.19

3.28

1.94e-07

MAP-196819

Vitamin B1 (thiamin) metabolism

2 of 5

2.94

1.47

0.0022

MAP-1855191

Synthesis of IPs in the nucleus

2 of 7

2.8

1.41

0.0028

MAP-1855167

Synthesis of pyrophosphates in the cytosol

2 of 10

2.64

1.3

0.0042

MAP-196849

Metabolism of water-soluble vitamins and cofactors

3 of 192

1.53

0.79

0.0228

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00149

Calcineurin-like phosphoesterase

3 of 14

2.67

2.15

0.00011

PF05770

Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain

2 of 2

3.34

1.6

0.0013

PF03770

Inositol polyphosphate kinase

2 of 9

2.69

1.15

0.0081

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