STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
USP46Ubiquitin carboxyl-terminal hydrolase. (381 aa)    
Predicted Functional Partners:
WDR48
WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes.
   
 
 0.968
WDR20
WD repeat domain 20.
   
 
 0.935
USP8-2
Rhodanese domain-containing protein.
 
    
 0.789
FANCD2
Uncharacterized protein.
    
 
 0.738
USP5
Ubiquitin carboxyl-terminal hydrolase.
      
 0.680
FANCI
Uncharacterized protein.
   
 
 0.647
TRIP12
Thyroid hormone receptor interactor 12.
      
 0.612
USP54
Ubiquitin specific peptidase 54.
      
 0.586
RAD51AP1
Uncharacterized protein.
    
 
 0.582
SLC16A14
Solute carrier family 16 member 14.
   
  
 0.573
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.