Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
ANXA6Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores (By similarity). (782 aa)    
Predicted Functional Partners:
TBC1D5
TBC1 domain family member 5.
    
   0.645
TRPC1
Transient receptor potential cation channel subfamily C member 1 isoform alpha; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.631
MAPT
Microtubule-associated protein.
    
 
 0.599
UEVLD
UEV domain-containing protein.
    
 
 0.598
DYSF
Uncharacterized protein.
   
  
 0.567
EFCC1
EF-hand domain-containing protein.
      
 0.546
NCAN
Uncharacterized protein.
      
 0.546
DRAXIN
Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord and cortical explants in vitro. Binds directly to the neurites and growth cones.
      
 0.521
BCL2
Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
      
 0.513
LYZ
Lysozyme C; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus; Belongs to the glycosyl hydrolase 22 family.
      
 0.502
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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