node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFG3L2 | HSPA9 | ENSGALP00000022434 | ENSGALP00000003717 | AFG3 like matrix AAA peptidase subunit 2. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. | 0.592 |
AFG3L2 | PHB | ENSGALP00000022434 | ENSGALP00000061263 | AFG3 like matrix AAA peptidase subunit 2. | Prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity). | 0.877 |
AFG3L2 | PHB2 | ENSGALP00000022434 | ENSGALP00000023446 | AFG3 like matrix AAA peptidase subunit 2. | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity); Belongs to the prohibitin family. | 0.843 |
AFG3L2 | PMPCA | ENSGALP00000022434 | ENSGALP00000003014 | AFG3 like matrix AAA peptidase subunit 2. | Uncharacterized protein; Belongs to the peptidase M16 family. | 0.736 |
AFG3L2 | SPG7 | ENSGALP00000022434 | ENSGALP00000041793 | AFG3 like matrix AAA peptidase subunit 2. | AAA domain-containing protein. | 0.841 |
AFG3L2 | STOML1 | ENSGALP00000022434 | ENSGALP00000002224 | AFG3 like matrix AAA peptidase subunit 2. | PHB domain-containing protein. | 0.587 |
AFG3L2 | STOML2 | ENSGALP00000022434 | ENSGALP00000003207 | AFG3 like matrix AAA peptidase subunit 2. | Stomatin like 2. | 0.536 |
AFG3L2 | STOML3 | ENSGALP00000022434 | ENSGALP00000027477 | AFG3 like matrix AAA peptidase subunit 2. | Stomatin like 3. | 0.517 |
AFG3L2 | YME1L1 | ENSGALP00000022434 | ENSGALP00000012098 | AFG3 like matrix AAA peptidase subunit 2. | AAA domain-containing protein. | 0.461 |
HSPA9 | AFG3L2 | ENSGALP00000003717 | ENSGALP00000022434 | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. | AFG3 like matrix AAA peptidase subunit 2. | 0.592 |
HSPA9 | PHB | ENSGALP00000003717 | ENSGALP00000061263 | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. | Prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity). | 0.718 |
HSPA9 | PHB2 | ENSGALP00000003717 | ENSGALP00000023446 | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity); Belongs to the prohibitin family. | 0.709 |
HSPA9 | PMPCA | ENSGALP00000003717 | ENSGALP00000003014 | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. | Uncharacterized protein; Belongs to the peptidase M16 family. | 0.454 |
HSPA9 | SPG7 | ENSGALP00000003717 | ENSGALP00000041793 | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. | AAA domain-containing protein. | 0.663 |
HSPA9 | VDAC1 | ENSGALP00000003717 | ENSGALP00000043741 | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. | Uncharacterized protein. | 0.982 |
HSPA9 | YME1L1 | ENSGALP00000003717 | ENSGALP00000012098 | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. | AAA domain-containing protein. | 0.538 |
PHB | AFG3L2 | ENSGALP00000061263 | ENSGALP00000022434 | Prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity). | AFG3 like matrix AAA peptidase subunit 2. | 0.877 |
PHB | HSPA9 | ENSGALP00000061263 | ENSGALP00000003717 | Prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity). | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. | 0.718 |
PHB | PHB2 | ENSGALP00000061263 | ENSGALP00000023446 | Prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity). | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity); Belongs to the prohibitin family. | 0.999 |
PHB | PMPCA | ENSGALP00000061263 | ENSGALP00000003014 | Prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity). | Uncharacterized protein; Belongs to the peptidase M16 family. | 0.709 |