STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PMVKPhosphomevalonate kinase. (188 aa)    
Predicted Functional Partners:
MVK
Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
   
 
 0.995
MVD
Mevalonate diphosphate decarboxylase.
   
 
 0.991
IDI2
Nudix hydrolase domain-containing protein.
   
 
 0.824
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
    
 
 0.771
FDPS
Farnesyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate; Belongs to the FPP/GGPP synthase family.
   
 
 0.737
DHCR7
Uncharacterized protein.
   
 
 0.728
DUSP21
Dual specificity phosphatase 21; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.
    
 
 0.706
HMGCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
   
  
 0.665
FDFT1
Uncharacterized protein.
   
  
 0.658
LSS
Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.
   
  
 0.658
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.