ACOT13 protein (Gallus gallus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

ACOT13

Acyl-CoA thioesterase 13. (143 aa)

Predicted Functional Partners:

UBIAD1

0.962

ACOT11

0.872

ACOT7

0.871

ACOT12

0.794

ACOT8

0.764

MCAT

0.757

OXSM

0.736

ACOT4-2

0.719

TNRC6B

0.706

HSDL2

0.664

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOT11	ACOT12	ENSGALP00000050424	ENSGALP00000025129	Acyl-CoA thioesterase 11.	Acyl-CoA thioesterase 12.	0.454
ACOT11	ACOT13	ENSGALP00000050424	ENSGALP00000063338	Acyl-CoA thioesterase 11.	Acyl-CoA thioesterase 13.	0.872
ACOT11	ACOT4-2	ENSGALP00000050424	ENSGALP00000073640	Acyl-CoA thioesterase 11.	Uncharacterized protein.	0.822
ACOT11	ACOT7	ENSGALP00000050424	ENSGALP00000000924	Acyl-CoA thioesterase 11.	Acyl-CoA thioesterase 7.	0.574
ACOT11	ACOT8	ENSGALP00000050424	ENSGALP00000011060	Acyl-CoA thioesterase 11.	Acyl-CoA thioesterase 8.	0.795
ACOT12	ACOT11	ENSGALP00000025129	ENSGALP00000050424	Acyl-CoA thioesterase 12.	Acyl-CoA thioesterase 11.	0.454
ACOT12	ACOT13	ENSGALP00000025129	ENSGALP00000063338	Acyl-CoA thioesterase 12.	Acyl-CoA thioesterase 13.	0.794
ACOT12	ACOT4-2	ENSGALP00000025129	ENSGALP00000073640	Acyl-CoA thioesterase 12.	Uncharacterized protein.	0.844
ACOT12	ACOT7	ENSGALP00000025129	ENSGALP00000000924	Acyl-CoA thioesterase 12.	Acyl-CoA thioesterase 7.	0.590
ACOT12	ACOT8	ENSGALP00000025129	ENSGALP00000011060	Acyl-CoA thioesterase 12.	Acyl-CoA thioesterase 8.	0.796
ACOT13	ACOT11	ENSGALP00000063338	ENSGALP00000050424	Acyl-CoA thioesterase 13.	Acyl-CoA thioesterase 11.	0.872
ACOT13	ACOT12	ENSGALP00000063338	ENSGALP00000025129	Acyl-CoA thioesterase 13.	Acyl-CoA thioesterase 12.	0.794
ACOT13	ACOT4-2	ENSGALP00000063338	ENSGALP00000073640	Acyl-CoA thioesterase 13.	Uncharacterized protein.	0.719
ACOT13	ACOT7	ENSGALP00000063338	ENSGALP00000000924	Acyl-CoA thioesterase 13.	Acyl-CoA thioesterase 7.	0.871
ACOT13	ACOT8	ENSGALP00000063338	ENSGALP00000011060	Acyl-CoA thioesterase 13.	Acyl-CoA thioesterase 8.	0.764
ACOT13	HSDL2	ENSGALP00000063338	ENSGALP00000025208	Acyl-CoA thioesterase 13.	Hydroxysteroid dehydrogenase like 2.	0.664
ACOT13	MCAT	ENSGALP00000063338	ENSGALP00000058421	Acyl-CoA thioesterase 13.	Malonyl-CoA-acyl carrier protein transacylase.	0.757
ACOT13	OXSM	ENSGALP00000063338	ENSGALP00000018434	Acyl-CoA thioesterase 13.	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.736
ACOT13	TNRC6B	ENSGALP00000063338	ENSGALP00000019656	Acyl-CoA thioesterase 13.	Trinucleotide repeat containing adaptor 6B.	0.706
ACOT13	UBIAD1	ENSGALP00000063338	ENSGALP00000005301	Acyl-CoA thioesterase 13.	UbiA prenyltransferase domain-containing protein 1; Prenyltransferase that mediates the formation of menaquinone- 4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzym [...]	0.962

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.895

expected number of edges:

11

PPI enrichment p-value:

1.9e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 100

1.34

2.22

1.96e-10

GO:0009059

Macromolecule biosynthetic process

11 of 164

1.17

1.72

1.96e-10

GO:0010467

Gene expression

11 of 187

1.11

1.57

1.96e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 244

1.0

1.26

1.51e-09

GO:0044238

Primary metabolic process

11 of 736

0.52

0.45

0.00011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 55

1.6

3.41

7.00e-13

GO:0019843

rRNA binding

8 of 41

1.64

3.03

5.68e-10

GO:0003723

RNA binding

9 of 99

1.3

1.97

4.42e-09

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.34

1.08

0.0103

GO:0000049

tRNA binding

3 of 24

1.44

0.83

0.0156

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 57

1.59

3.45

1.16e-13

GO:0044391

Ribosomal subunit

4 of 14

1.8

2.22

9.87e-06

GO:0015934

Large ribosomal subunit

3 of 8

1.92

1.89

0.00012

GO:0032991

Protein-containing complex

5 of 143

0.89

0.69

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27330141

(2016) Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity.

7 of 26

1.78

2.96

3.35e-08

PMID:28977619

(2017) The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression.

8 of 51

1.54

2.45

3.35e-08

PMID:22043294

(2011) Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

4 of 8

2.04

1.98

0.00011

PMID:20019804

(2009) Transcriptome and proteome exploration to model translation efficiency and protein stability in Lactococcus lactis.

6 of 65

1.31

1.32

0.00015

PMID:30779773

(2019) Multiplexing polysome profiling experiments to study translation in Escherichia coli.

3 of 7

1.98

1.24

0.0040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:95

rRNA-binding

8 of 31

1.76

3.73

1.37e-11

CL:86

Ribosome, and Translational elongation

11 of 69

1.55

3.38

1.30e-14

CL:89

Ribosome

10 of 59

1.57

3.36

2.01e-13

CL:91

Ribosome

9 of 50

1.6

3.28

4.05e-12

CL:147

Large ribosomal subunit rRNA binding, and Translation regulation

4 of 5

2.25

3.03

9.25e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

llm03010

Ribosome

10 of 55

1.6

3.53

9.24e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015934

Large ribosomal subunit

5 of 10

2.04

3.23

1.01e-07

GOCC:0005840

Ribosome

8 of 45

1.59

2.87

9.60e-10

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 6

2.04

1.94

0.00013

GOCC:0043229

Intracellular organelle

10 of 224

0.99

1.19

5.88e-08

GOCC:0032991

Protein-containing complex

6 of 331

0.6

0.38

0.0297

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 56

1.6

3.45

2.01e-13

KW-0699

rRNA-binding

8 of 39

1.66

3.24

9.68e-11

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