STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GIPGLUCAGON domain-containing protein. (139 aa)    
Predicted Functional Partners:
GIPR
Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.
    
 0.972
DPP4
Uncharacterized protein; Belongs to the peptidase S9B family.
     
 0.931
GCG
Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis.
      
 0.875
GLP1R
Glucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family.
    
 
 0.860
PYY
Peptide YY-like; This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. Belongs to the NPY family.
      
 0.847
GPR119
G protein-coupled receptor 119.
    
 0.824
GCGR
Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.
    
 
 0.775
GHRL
Preproghrelin.
      
 0.767
CCK
Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.
      
 0.765
LOC100858942
Glucagon type II.
    
 
 0.744
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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