STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GLIS2Uncharacterized protein. (649 aa)    
Predicted Functional Partners:
ARMC8
Uncharacterized protein.
      
 0.704
GPSM2
G protein signaling modulator 2.
    
 
 0.667
CBFA2T3
Protein CBFA2T3; Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors. Plays a role in granulocyte differentiation. May also function as an A-kinase- anchoring protein (By similarity); Belongs to the CBFA2T family.
   
 
 0.642
GLIS1
GLIS family zinc finger 1.
    
 
 0.606
GLIS3
GLIS family zinc finger 3.
    
 
 0.605
GRHL1
TATA box-binding protein-associated factor RNA polymerase I subunit B.
    
 
 0.595
NPHP1
SH3 domain-containing protein.
    
 
 0.590
WNK1
WNK lysine deficient protein kinase 1.
   
 
 0.569
ZBTB7A
Zinc finger and BTB domain-containing protein 7A; Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation. Directly and specifically binds to the consensus sequence 5'- [GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ [...]
   
  
 0.545
INVS
Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity).
    
 
 0.533
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.