node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBLL1 | FBXL20 | ENSGALP00000052986 | ENSGALP00000002570 | E3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing; Belongs to the Hakai family. | F-box and leucine rich repeat protein 20. | 0.420 |
CBLL1 | MARCH8 | ENSGALP00000052986 | ENSGALP00000069069 | E3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing; Belongs to the Hakai family. | RING-CH-type domain-containing protein. | 0.488 |
CNOT2 | FBXL20 | ENSGALP00000016295 | ENSGALP00000002570 | NOT2_3_5 domain-containing protein. | F-box and leucine rich repeat protein 20. | 0.479 |
CNOT2 | MARCH8 | ENSGALP00000016295 | ENSGALP00000069069 | NOT2_3_5 domain-containing protein. | RING-CH-type domain-containing protein. | 0.589 |
FBXL20 | CBLL1 | ENSGALP00000002570 | ENSGALP00000052986 | F-box and leucine rich repeat protein 20. | E3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing; Belongs to the Hakai family. | 0.420 |
FBXL20 | CNOT2 | ENSGALP00000002570 | ENSGALP00000016295 | F-box and leucine rich repeat protein 20. | NOT2_3_5 domain-containing protein. | 0.479 |
FBXL20 | MARCH8 | ENSGALP00000002570 | ENSGALP00000069069 | F-box and leucine rich repeat protein 20. | RING-CH-type domain-containing protein. | 0.634 |
FBXL20 | UBR1 | ENSGALP00000002570 | ENSGALP00000015034 | F-box and leucine rich repeat protein 20. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.722 |
MARCH5 | MARCH8 | ENSGALP00000054982 | ENSGALP00000069069 | E3 ubiquitin-protein ligase MARCHF5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. | RING-CH-type domain-containing protein. | 0.752 |
MARCH5 | RNF5 | ENSGALP00000054982 | ENSGALP00000068585 | E3 ubiquitin-protein ligase MARCHF5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and [...] | 0.793 |
MARCH8 | CBLL1 | ENSGALP00000069069 | ENSGALP00000052986 | RING-CH-type domain-containing protein. | E3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing; Belongs to the Hakai family. | 0.488 |
MARCH8 | CNOT2 | ENSGALP00000069069 | ENSGALP00000016295 | RING-CH-type domain-containing protein. | NOT2_3_5 domain-containing protein. | 0.589 |
MARCH8 | FBXL20 | ENSGALP00000069069 | ENSGALP00000002570 | RING-CH-type domain-containing protein. | F-box and leucine rich repeat protein 20. | 0.634 |
MARCH8 | MARCH5 | ENSGALP00000069069 | ENSGALP00000054982 | RING-CH-type domain-containing protein. | E3 ubiquitin-protein ligase MARCHF5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. | 0.752 |
MARCH8 | NBR1 | ENSGALP00000069069 | ENSGALP00000004357 | RING-CH-type domain-containing protein. | NBR1 autophagy cargo receptor. | 0.478 |
MARCH8 | REV1 | ENSGALP00000069069 | ENSGALP00000066817 | RING-CH-type domain-containing protein. | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity). May play a role in homologous recombination and immunoglobulin gene conversion; Belongs to the DNA polymerase type-Y family. | 0.529 |
MARCH8 | RNF5 | ENSGALP00000069069 | ENSGALP00000068585 | RING-CH-type domain-containing protein. | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and [...] | 0.574 |
MARCH8 | UBR1 | ENSGALP00000069069 | ENSGALP00000015034 | RING-CH-type domain-containing protein. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.653 |
MARCH8 | USP25 | ENSGALP00000069069 | ENSGALP00000025263 | RING-CH-type domain-containing protein. | Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. | 0.546 |
MARCH8 | ZFX | ENSGALP00000069069 | ENSGALP00000026288 | RING-CH-type domain-containing protein. | Uncharacterized protein. | 0.515 |