EDMPN2 protein (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EDMPN2

Epidermal differentiation protein. (83 aa)

Predicted Functional Partners:

EDQM3

0.950

LOC101751162

0.950

EDYM1

0.925

LOC107049024

0.860

LOC107055124

0.706

LOC107055134

0.705

LOC107055132

0.702

LOC107055125

0.701

EDBETA

0.534

CRNN

0.477

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRNN	EDBETA	ENSGALP00000041244	ENSGALP00000056126	EF-hand domain-containing protein.	Keratin.	0.537
CRNN	EDMPN2	ENSGALP00000041244	ENSGALP00000069275	EF-hand domain-containing protein.	Epidermal differentiation protein.	0.477
CRNN	EDQM3	ENSGALP00000041244	ENSGALP00000052187	EF-hand domain-containing protein.	Epidermal differentiation protein.	0.743
CRNN	EDYM1	ENSGALP00000041244	ENSGALP00000054110	EF-hand domain-containing protein.	Uncharacterized protein.	0.850
CRNN	LOC101751162	ENSGALP00000041244	ENSGALP00000072701	EF-hand domain-containing protein.	Epidermal differentiation protein.	0.850
CRNN	LOC107049024	ENSGALP00000041244	ENSGALP00000054987	EF-hand domain-containing protein.	Epidermal differentiation protein.	0.848
CRNN	LOC107055124	ENSGALP00000041244	ENSGALP00000066853	EF-hand domain-containing protein.	Uncharacterized LOC107055124.	0.583
CRNN	LOC107055125	ENSGALP00000041244	ENSGALP00000048126	EF-hand domain-containing protein.	Uncharacterized protein.	0.517
CRNN	LOC107055132	ENSGALP00000041244	ENSGALP00000045775	EF-hand domain-containing protein.	Uncharacterized protein.	0.709
CRNN	LOC107055134	ENSGALP00000041244	ENSGALP00000060726	EF-hand domain-containing protein.	Uncharacterized protein.	0.952
EDBETA	CRNN	ENSGALP00000056126	ENSGALP00000041244	Keratin.	EF-hand domain-containing protein.	0.537
EDBETA	EDMPN2	ENSGALP00000056126	ENSGALP00000069275	Keratin.	Epidermal differentiation protein.	0.534
EDBETA	EDQM3	ENSGALP00000056126	ENSGALP00000052187	Keratin.	Epidermal differentiation protein.	0.789
EDBETA	EDYM1	ENSGALP00000056126	ENSGALP00000054110	Keratin.	Uncharacterized protein.	0.602
EDBETA	LOC101751162	ENSGALP00000056126	ENSGALP00000072701	Keratin.	Epidermal differentiation protein.	0.651
EDBETA	LOC107049024	ENSGALP00000056126	ENSGALP00000054987	Keratin.	Epidermal differentiation protein.	0.749
EDBETA	LOC107055124	ENSGALP00000056126	ENSGALP00000066853	Keratin.	Uncharacterized LOC107055124.	0.860
EDBETA	LOC107055125	ENSGALP00000056126	ENSGALP00000048126	Keratin.	Uncharacterized protein.	0.951
EDBETA	LOC107055132	ENSGALP00000056126	ENSGALP00000045775	Keratin.	Uncharacterized protein.	0.767
EDBETA	LOC107055134	ENSGALP00000056126	ENSGALP00000060726	Keratin.	Uncharacterized protein.	0.626

page 1 of 6

Network Stats

Network Stats analysis is still ongoing, please wait ...

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032446

Protein modification by small protein conjugation

7 of 663

1.27

1.29

0.00014

GO:0006513

Protein monoubiquitination

3 of 51

2.02

1.12

0.0073

GO:0016567

Protein ubiquitination

6 of 609

1.24

1.06

0.0011

GO:0032465

Regulation of cytokinesis

3 of 74

1.86

0.91

0.0171

GO:0045116

Protein neddylation

2 of 12

2.47

0.77

0.0393

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061629

RNA polymerase II-specific DNA-binding transcription factor binding

4 of 212

1.53

0.9

0.0121

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031463

Cul3-RING ubiquitin ligase complex

6 of 37

2.46

5.16

4.72e-11

GO:0005827

Polar microtubule

3 of 4

3.13

3.2

1.52e-06

GO:0034464

BBSome

2 of 8

2.65

1.49

0.0019

GO:0005819

Spindle

4 of 287

1.39

1.12

0.0019

GO:0060170

Ciliary membrane

2 of 51

1.84

0.83

0.0251

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23920

Kelch, and BBSome

8 of 44

2.51

7.27

9.86e-16

CL:23978

Cul3-RING ubiquitin ligase complex

4 of 10

2.85

4.18

1.77e-08

CL:23930

BBSome, and Fatty acid transmembrane transporter activity

4 of 16

2.65

3.78

7.41e-08

CL:23979

Cul3-RING ubiquitin ligase complex

3 of 5

3.03

3.16

1.75e-06

CL:23935

BBSome, and Regulation of protein localization to ciliary membrane

3 of 10

2.73

2.75

8.46e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lcm04120

Ubiquitin mediated proteolysis

3 of 109

1.69

1.12

0.0048

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951664

Neddylation

9 of 343

1.67

3.43

1.55e-11

MAP-983168

Antigen processing: Ubiquitination & Proteasome degradation

8 of 432

1.52

2.5

7.78e-09

MAP-983169

Class I MHC mediated antigen processing & presentation

8 of 512

1.44

2.25

1.97e-08

MAP-1280218

Adaptive Immune System

8 of 994

1.16

1.37

2.70e-06

MAP-5620922

BBSome-mediated cargo-targeting to cilium

2 of 14

2.41

1.17

0.0070

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031463

Cul3-RING ubiquitin ligase complex

4 of 36

2.3

2.64

7.46e-06

GOCC:0005827

Polar microtubule

2 of 2

3.25

1.6

0.0013

GOCC:0034464

BBSome

2 of 7

2.71

1.37

0.0032

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0880

Kelch repeat

6 of 51

2.32

4.89

6.91e-11

KW-0677

Repeat

6 of 955

1.05

0.9

0.00084

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017096

BTB-kelch protein

6 of 44

2.38

4.57

6.09e-10

IPR011705

BTB/Kelch-associated

6 of 63

2.23

4.13

2.29e-09

IPR006652

Kelch repeat type 1

6 of 68

2.2

4.08

2.35e-09

IPR015915

Kelch-type beta propeller

6 of 79

2.13

3.89

4.16e-09

IPR000210

BTB/POZ domain

6 of 189

1.75

2.57

5.25e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00612

Kelch

6 of 60

2.25

4.47

4.03e-10

SM00875

BTB And C-terminal Kelch

6 of 62

2.24

4.45

4.03e-10

SM00225

Broad-Complex, Tramtrack and Bric a brac

6 of 179

1.78

2.86

7.38e-08

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Cooccurrence

Experiments

Neighborhood

Textmining

Fusion

Databases

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About