STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CASZ1Castor zinc finger 1. (1967 aa)    
Predicted Functional Partners:
IKZF1
DNA-binding protein Ikaros; Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T- cell development. Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity).
      
 0.546
PLCH2
Phosphoinositide phospholipase C.
      
 0.499
RP1-27O5.3
Uncharacterized protein.
      
 0.499
SH2B3
SH2B adaptor protein 3.
      
 0.490
ECD
Uncharacterized protein.
      
 0.473
GINS4
Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
      
 0.445
ISOC1
Isochorismatase domain containing 1.
      
 0.428
SAMD7
Sterile alpha motif domain containing 7.
      
 0.423
N4BP1
NEDD4-binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Belongs to the N4BP1 family.
      
 0.416
SAMD11
Uncharacterized protein.
      
 0.408
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.