STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PHF2PHD finger protein 2. (1132 aa)    
Predicted Functional Partners:
MAPK1IP1L
Mitogen-activated protein kinase 1 interacting protein 1 like.
    
 
 0.748
STARD5
StAR related lipid transfer domain containing 5.
      
 0.677
MAPK8IP3
Mitogen-activated protein kinase 8 interacting protein 3.
   
  
 0.587
GRK6
G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
      
 0.582
SKP1
S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity).
   
 
 0.560
SETD2
SET domain containing 2, histone lysine methyltransferase.
   
 
 0.525
RNF2
Ring finger protein 2.
   
 
 0.525
TOPBP1
DNA topoisomerase II binding protein 1.
    
   0.509
RPS4Y1
40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family.
      
 0.501
MAPKAP1
Target of rapamycin complex 2 subunit MAPKAP1; Essential component of the TORC2 complex, which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity); Belongs to the SIN1 family.
      
 0.499
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.