FSTL4 protein (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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Experiments

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[Homology]

Score

FSTL4

Uncharacterized protein. (923 aa)

Predicted Functional Partners:

PTPRG

0.626

SH2D4A

0.615

HHATL

0.609

FSTL3

0.608

CRTC1

0.600

MLLT6

0.600

GALNT17

0.534

DENND5B

0.524

LRRTM3

0.507

DRD4

0.499

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRTC1	FSTL4	ENSGALP00000005227	ENSGALP00000073385	CREB regulated transcription coactivator 1.	Uncharacterized protein.	0.600
DENND5B	FSTL4	ENSGALP00000070859	ENSGALP00000073385	DENN domain containing 5B.	Uncharacterized protein.	0.524
DENND5B	MLLT6	ENSGALP00000070859	ENSGALP00000044191	DENN domain containing 5B.	MLLT6, PHD finger containing.	0.722
DENND5B	SH2D4A	ENSGALP00000070859	ENSGALP00000016445	DENN domain containing 5B.	SH2 domain containing 4A.	0.721
DRD4	FSTL4	ENSGALP00000052151	ENSGALP00000073385	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.499
DRD4	HHATL	ENSGALP00000052151	ENSGALP00000008480	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	0.483
FSTL3	FSTL4	ENSGALP00000072662	ENSGALP00000073385	Follistatin like 3.	Uncharacterized protein.	0.608
FSTL4	CRTC1	ENSGALP00000073385	ENSGALP00000005227	Uncharacterized protein.	CREB regulated transcription coactivator 1.	0.600
FSTL4	DENND5B	ENSGALP00000073385	ENSGALP00000070859	Uncharacterized protein.	DENN domain containing 5B.	0.524
FSTL4	DRD4	ENSGALP00000073385	ENSGALP00000052151	Uncharacterized protein.	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.	0.499
FSTL4	FSTL3	ENSGALP00000073385	ENSGALP00000072662	Uncharacterized protein.	Follistatin like 3.	0.608
FSTL4	GALNT17	ENSGALP00000073385	ENSGALP00000001704	Uncharacterized protein.	Polypeptide N-acetylgalactosaminyltransferase.	0.534
FSTL4	HHATL	ENSGALP00000073385	ENSGALP00000008480	Uncharacterized protein.	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	0.609
FSTL4	LRRTM3	ENSGALP00000073385	ENSGALP00000033454	Uncharacterized protein.	LRRNT domain-containing protein.	0.507
FSTL4	MLLT6	ENSGALP00000073385	ENSGALP00000044191	Uncharacterized protein.	MLLT6, PHD finger containing.	0.600
FSTL4	PTPRG	ENSGALP00000073385	ENSGALP00000043685	Uncharacterized protein.	Receptor-type tyrosine-protein phosphatase gamma; Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.	0.626
FSTL4	SH2D4A	ENSGALP00000073385	ENSGALP00000016445	Uncharacterized protein.	SH2 domain containing 4A.	0.615
GALNT17	FSTL4	ENSGALP00000001704	ENSGALP00000073385	Polypeptide N-acetylgalactosaminyltransferase.	Uncharacterized protein.	0.534
HHATL	DRD4	ENSGALP00000008480	ENSGALP00000052151	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.	0.483
HHATL	FSTL4	ENSGALP00000008480	ENSGALP00000073385	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	Uncharacterized protein.	0.609

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.966

expected number of edges:

33

PPI enrichment p-value:

0.24

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

8 of 104

1.18

1.4

2.81e-06

GO:0019538

Protein metabolic process

10 of 228

0.93

1.0

2.09e-06

GO:0044271

Cellular nitrogen compound biosynthetic process

9 of 254

0.84

0.81

2.41e-05

GO:1901566

Organonitrogen compound biosynthetic process

9 of 276

0.8

0.75

4.42e-05

GO:1901564

Organonitrogen compound metabolic process

11 of 473

0.66

0.61

8.82e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

7 of 53

1.41

1.88

1.33e-06

GO:0019843

rRNA binding

4 of 41

1.28

0.86

0.0080

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

7 of 55

1.4

1.96

3.12e-07

GO:0044391

Ribosomal subunit

2 of 15

1.42

0.64

0.0470

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:106

Structural constituent of ribosome

7 of 54

1.4

2.01

1.74e-07

CL:103

Structural constituent of ribosome, and Elongation factor

8 of 68

1.36

1.99

5.59e-08

CL:85

Mixed, incl. Translation, and Oxidative phosphorylation

10 of 168

1.07

1.33

5.27e-08

CL:146

Ribosomal protein

3 of 17

1.54

1.13

0.0031

CL:108

Structural constituent of ribosome

4 of 42

1.27

1.05

0.0016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

7 of 54

1.4

1.97

3.20e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

7 of 42

1.51

2.28

1.22e-07

GOCC:0044391

Ribosomal subunit

5 of 22

1.65

2.05

9.09e-06

GOCC:0022626

Cytosolic ribosome

4 of 16

1.69

1.85

5.67e-05

GOCC:0022627

Cytosolic small ribosomal subunit

3 of 10

1.77

1.5

0.00070

GOCC:0015934

Large ribosomal subunit

2 of 10

1.59

0.77

0.0277

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

7 of 53

1.41

1.96

4.58e-07

KW-0699

rRNA-binding

4 of 39

1.3

1.03

0.0023

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