POM121C protein (Gallus gallus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

POM121C

Uncharacterized protein. (877 aa)

Predicted Functional Partners:

NUP153

0.866

NUP188

0.862

NUP98

0.839

NUP93

0.828

NUP35

0.822

NUP50

0.822

NUP43

0.821

NUP155

0.810

NUP205

0.808

NUP214

0.806

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NUP153	NUP155	ENSGALP00000057748	ENSGALP00000005832	Nucleoporin 153.	Nucleoporin 155.	0.992
NUP153	NUP188	ENSGALP00000057748	ENSGALP00000058268	Nucleoporin 153.	Uncharacterized protein.	0.936
NUP153	NUP205	ENSGALP00000057748	ENSGALP00000051764	Nucleoporin 153.	Nucleoporin 205.	0.990
NUP153	NUP214	ENSGALP00000057748	ENSGALP00000053022	Nucleoporin 153.	Nucleoporin 214.	0.998
NUP153	NUP35	ENSGALP00000057748	ENSGALP00000004227	Nucleoporin 153.	Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family.	0.984
NUP153	NUP43	ENSGALP00000057748	ENSGALP00000020198	Nucleoporin 153.	Nucleoporin 43.	0.955
NUP153	NUP50	ENSGALP00000057748	ENSGALP00000022956	Nucleoporin 153.	RanBD1 domain-containing protein.	0.998
NUP153	NUP93	ENSGALP00000057748	ENSGALP00000051586	Nucleoporin 153.	Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family.	0.996
NUP153	NUP98	ENSGALP00000057748	ENSGALP00000050065	Nucleoporin 153.	Nucleoporin 98.	0.990
NUP153	POM121C	ENSGALP00000057748	ENSGALP00000073569	Nucleoporin 153.	Uncharacterized protein.	0.866
NUP155	NUP153	ENSGALP00000005832	ENSGALP00000057748	Nucleoporin 155.	Nucleoporin 153.	0.992
NUP155	NUP188	ENSGALP00000005832	ENSGALP00000058268	Nucleoporin 155.	Uncharacterized protein.	0.997
NUP155	NUP205	ENSGALP00000005832	ENSGALP00000051764	Nucleoporin 155.	Nucleoporin 205.	0.999
NUP155	NUP214	ENSGALP00000005832	ENSGALP00000053022	Nucleoporin 155.	Nucleoporin 214.	0.992
NUP155	NUP35	ENSGALP00000005832	ENSGALP00000004227	Nucleoporin 155.	Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family.	0.999
NUP155	NUP43	ENSGALP00000005832	ENSGALP00000020198	Nucleoporin 155.	Nucleoporin 43.	0.984
NUP155	NUP50	ENSGALP00000005832	ENSGALP00000022956	Nucleoporin 155.	RanBD1 domain-containing protein.	0.924
NUP155	NUP93	ENSGALP00000005832	ENSGALP00000051586	Nucleoporin 155.	Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family.	0.999
NUP155	NUP98	ENSGALP00000005832	ENSGALP00000050065	Nucleoporin 155.	Nucleoporin 98.	0.999
NUP155	POM121C	ENSGALP00000005832	ENSGALP00000073569	Nucleoporin 155.	Uncharacterized protein.	0.810

page 1 of 6

Network Stats

number of nodes:

6

number of edges:

12

average node degree:

4

avg. local clustering coefficient:

0.844

expected number of edges:

5

PPI enrichment p-value:

0.00633

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019221

Cytokine-mediated signaling pathway

6 of 259

1.91

3.19

1.47e-07

GO:0050829

Defense response to Gram-negative bacterium

3 of 21

2.7

2.62

4.32e-05

GO:0002920

Regulation of humoral immune response

3 of 20

2.72

2.62

4.32e-05

GO:0002225

Positive regulation of antimicrobial peptide production

2 of 2

3.55

2.17

0.00031

GO:0050830

Defense response to Gram-positive bacterium

3 of 57

2.27

2.02

0.00032

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004896

Cytokine receptor activity

3 of 96

2.04

1.26

0.0063

GO:0005125

Cytokine activity

3 of 128

1.92

1.24

0.0063

GO:0048018

Receptor ligand activity

4 of 439

1.51

1.08

0.0063

GO:0046982

Protein heterodimerization activity

3 of 284

1.57

0.88

0.0218

GO:0046983

Protein dimerization activity

4 of 938

1.18

0.69

0.0264

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31523510

(2019) Marked variations in gut microbiota and some innate immune responses of fresh water crayfish, marron (Cherax cainii, Austin 2002) fed dietary supplementation of Clostridium butyricum.

3 of 14

2.88

2.61

4.88e-05

PMID:36712402

(2023) Functionality of dietary antimicrobial peptides in aquatic animal health: Multiple meta-analyses.

2 of 10

2.85

1.2

0.0111

PMID:28094307

(2017) A transcriptome analysis focusing on inflammation-related genes of grass carp intestines following infection with Aeromonas hydrophila.

2 of 15

2.67

1.11

0.0153

PMID:31649660

(2019) A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish.

2 of 28

2.4

0.87

0.0365

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19672

Regulation of IFNG signaling, and STAT protein, protein interaction domain

5 of 22

2.9

5.77

1.77e-10

CL:19706

Interleukin-10/19/20/22/24/26 family, and Regulation of IFNG signaling

4 of 5

3.45

5.67

5.46e-10

CL:34679

SEFIR domain, and Interleukin-17 family

3 of 10

3.02

3.4

2.48e-06

CL:34682

Regulation of antimicrobial peptide production, and Interleukin-17 receptor, fibronectin-III-like domain 1

2 of 5

3.15

1.97

0.00061

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

onl04060

Cytokine-cytokine receptor interaction

6 of 254

1.92

3.79

2.68e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6785807

Interleukin-4 and Interleukin-13 signaling

4 of 42

2.53

3.55

7.24e-07

MAP-877312

Regulation of IFNG signaling

3 of 13

2.91

3.22

4.68e-06

MAP-5663205

Infectious disease

4 of 98

2.16

2.89

4.68e-06

MAP-912694

Regulation of IFNA/IFNB signaling

3 of 27

2.59

2.78

2.03e-05

MAP-1643685

Disease

4 of 174

1.91

2.3

2.95e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070743

interleukin-23 complex

3 of 7

3.18

3.39

2.79e-06

GOCC:0005615

Extracellular space

4 of 522

1.43

1.04

0.0061

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06083

Interleukin-17

3 of 8

3.12

3.19

5.90e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020440

Interleukin-17, chordata

3 of 6

3.25

3.13

7.70e-06

IPR010345

Interleukin-17 family

3 of 6

3.25

3.13

7.70e-06

IPR020443

Interleukin-10/19/20/22/24/26 family

2 of 3

3.37

1.8

0.0012

IPR029034

Cystine-knot cytokine

3 of 60

2.25

1.7

0.0012

IPR009079

Four-helical cytokine-like, core

2 of 23

2.49

0.96

0.0258

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