STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
STY3792Putative aldolase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family. (291 aa)    
Predicted Functional Partners:
STY3793
Putative ABC transport protein, solute-binding component; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity).
 
  
 0.994
STY3791
Conserved hypothetical protein; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD); Belongs to the LsrG family.
 
  
 0.993
STY3794
Putative ABC transporter, membrane component; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (By similarity).
 
  
 0.961
STY3798
Putative sugar kinase; Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.
 
  
 0.952
STY3797
Putative regulatory protein; In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFGE operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes (By similarity).
 
  
 0.946
STY3795
Putative ABC transporter permease protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (By similarity).
 
  
 0.872
STY3796
Putative ABC transporter ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (By similarity).
 
  
 0.863
STY3790
Similar to several Prokaryotic and Eukaryotic ribulose-phosphate 3-epimerases e.g. Bacillus subtilis RpE SW:RPE_BACSU (O34557) (217 aa) fasta scores: E(): 9.4e-16, 30.3% id in 208 aa and to Oryza sativa SW:RPE_ORYSA (Q9ZTP5) (274 aa) fasta scores: E(): 2.7e-13, 29.8% id in 208 aa.
  
    0.696
STY3799
Hypothetical protein; No significant database hits.
 
    0.646
rpe
Similar to Escherichia coli ribulose-phosphate 3-epimerase rpe or doD SW:RPE_ECOLI (P32661) (225 aa) fasta scores: E(): 0, 97.3% id in 225 aa, and to Serratia marcescens ribulose-phosphate 3-epimerase rpe or doD SW:RPE_SERMA (P45455) (210 aa) fasta scores: E(): 0, 87.1% id in 210 aa.
  
  
 0.634
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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