Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ESR1Estrogen receptor 1. (512 aa)    
Predicted Functional Partners:
ESR2
Estrogen receptor 2.
    
 0.999
PGR
Progesterone receptor.
   
 0.998
MED1
Mediator complex subunit 1.
    
 0.997
SP1
Sp1 transcription factor.
    
 0.997
EP300
E1A binding protein p300.
    
 0.996
CREBBP
CREB binding protein.
    
 0.994
NRIP1
Nuclear receptor interacting protein 1.
    
 0.992
PTGES3
Prostaglandin E synthase 3.
   
 0.992
SRC
SRC proto-oncogene, non-receptor tyrosine kinase.
    
 0.991
FOS
Fos proto-oncogene, AP-1 transcription factor subunit.
    
 0.990
Your Current Organism:
Pavo cristatus
NCBI taxonomy Id: 9049
Other names: Indian peafowl, P. cristatus, blue peafowl
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