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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMPDL3BSphingomyelin phosphodiesterase acid like 3B. (501 aa)    
Predicted Functional Partners:
ASAH1
N-acylsphingosine amidohydrolase 1.
   
 0.781
SMPD2
Sphingomyelin phosphodiesterase 2.
     
 0.773
ENSPSTP00000021871
annotation not available
     
 0.771
TMEM130
Transmembrane protein 130.
   
 
 0.742
ACER1
Alkaline ceramidase 1.
     
 0.693
ENSPSTP00000023529
annotation not available
     
 0.692
PLPP2
Phospholipid phosphatase 2.
     
 0.674
GBA2
Glucosylceramidase beta 2.
     
 0.660
SPHK1
Sphingosine kinase 1.
    
 0.654
PLPP1
Phospholipid phosphatase 1.
     
 0.651
Your Current Organism:
Pavo cristatus
NCBI taxonomy Id: 9049
Other names: Indian peafowl, P. cristatus, blue peafowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.