L1I5V7_GUITC protein (Guillardia theta) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

L1I5V7_GUITC

tRNA-synt_1 domain-containing protein. (357 aa)

Predicted Functional Partners:

L1J482_GUITC

0.965

L1ILU9_GUITC

0.950

L1IY40_GUITC

0.906

L1JU52_GUITC

0.873

L1JBT3_GUITC

0.749

L1K339_GUITC

0.733

L1JGM6_GUITC

0.723

L1K156_GUITC

0.723

L1IQT0_GUITC

0.706

L1JM17_GUITC

0.706

Your Current Organism:

Guillardia theta

NCBI taxonomy Id: 905079
Other names: G. theta CCMP2712, Guillardia theta CCMP2712

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L1I5V7_GUITC	L1ILU9_GUITC	L1I5V7	L1ILU9	tRNA-synt_1 domain-containing protein.	Uncharacterized protein.	0.950
L1I5V7_GUITC	L1IQT0_GUITC	L1I5V7	L1IQT0	tRNA-synt_1 domain-containing protein.	Leucyl-tRNA synthetase, PPC-targeted; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.706
L1I5V7_GUITC	L1IY40_GUITC	L1I5V7	L1IY40	tRNA-synt_1 domain-containing protein.	Brix domain-containing protein.	0.906
L1I5V7_GUITC	L1J482_GUITC	L1I5V7	L1J482	tRNA-synt_1 domain-containing protein.	Uncharacterized protein.	0.965
L1I5V7_GUITC	L1JBT3_GUITC	L1I5V7	L1JBT3	tRNA-synt_1 domain-containing protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.749
L1I5V7_GUITC	L1JGM6_GUITC	L1I5V7	L1JGM6	tRNA-synt_1 domain-containing protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.723
L1I5V7_GUITC	L1JM17_GUITC	L1I5V7	L1JM17	tRNA-synt_1 domain-containing protein.	Uncharacterized protein.	0.706
L1I5V7_GUITC	L1JU52_GUITC	L1I5V7	L1JU52	tRNA-synt_1 domain-containing protein.	Mannosyltransferase.	0.873
L1I5V7_GUITC	L1K156_GUITC	L1I5V7	L1K156	tRNA-synt_1 domain-containing protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.723
L1I5V7_GUITC	L1K339_GUITC	L1I5V7	L1K339	tRNA-synt_1 domain-containing protein.	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.733
L1ILU9_GUITC	L1I5V7_GUITC	L1ILU9	L1I5V7	Uncharacterized protein.	tRNA-synt_1 domain-containing protein.	0.950
L1ILU9_GUITC	L1IQT0_GUITC	L1ILU9	L1IQT0	Uncharacterized protein.	Leucyl-tRNA synthetase, PPC-targeted; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.706
L1ILU9_GUITC	L1J482_GUITC	L1ILU9	L1J482	Uncharacterized protein.	Uncharacterized protein.	0.965
L1ILU9_GUITC	L1JBT3_GUITC	L1ILU9	L1JBT3	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.749
L1ILU9_GUITC	L1JGM6_GUITC	L1ILU9	L1JGM6	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.723
L1ILU9_GUITC	L1JM17_GUITC	L1ILU9	L1JM17	Uncharacterized protein.	Uncharacterized protein.	0.706
L1ILU9_GUITC	L1K156_GUITC	L1ILU9	L1K156	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.723
L1ILU9_GUITC	L1K339_GUITC	L1ILU9	L1K339	Uncharacterized protein.	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.733
L1IQT0_GUITC	L1I5V7_GUITC	L1IQT0	L1I5V7	Leucyl-tRNA synthetase, PPC-targeted; Belongs to the class-I aminoacyl-tRNA synthetase family.	tRNA-synt_1 domain-containing protein.	0.706
L1IQT0_GUITC	L1ILU9_GUITC	L1IQT0	L1ILU9	Leucyl-tRNA synthetase, PPC-targeted; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uncharacterized protein.	0.706

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.872

expected number of edges:

10

PPI enrichment p-value:

0.000353

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055088

Lipid homeostasis

5 of 17

2.61

4.52

2.16e-09

GO:0006654

Phosphatidic acid biosynthetic process

4 of 5

3.05

4.27

1.52e-08

GO:0006629

Lipid metabolic process

11 of 427

1.56

3.39

2.28e-14

GO:0046486

Glycerolipid metabolic process

5 of 184

1.58

1.77

4.23e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042171

Lysophosphatidic acid acyltransferase activity

4 of 4

3.14

4.49

6.26e-09

GO:0052689

Carboxylic ester hydrolase activity

5 of 64

2.04

3.13

1.80e-07

GO:0016788

Hydrolase activity, acting on ester bonds

11 of 505

1.48

3.04

6.98e-14

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13767

Mixed, incl. Acylglycerol metabolic process, and Keratinization

11 of 45

2.53

10.86

1.20e-24

CL:13796

Partial AB-hydrolase lipase domain

6 of 6

3.14

7.5

1.32e-14

CL:13841

Lysophosphatidic acid acyltransferase activity, and Patatin-like phospholipase domain-containing protein

5 of 8

2.94

5.64

3.15e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00100

Steroid biosynthesis

6 of 18

2.67

6.34

4.58e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6809371

Formation of the cornified envelope

6 of 8

3.02

7.08

6.19e-14

MAP-6805567

Keratinization

6 of 8

3.02

7.08

6.19e-14

MAP-1266738

Developmental Biology

6 of 50

2.22

4.53

2.21e-10

MAP-1482839

Acyl chain remodelling of PE

4 of 7

2.9

4.33

9.55e-09

MAP-1483206

Glycerophospholipid biosynthesis

4 of 117

1.68

1.65

0.00019

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0442

Lipid degradation

4 of 14

2.6

3.7

9.75e-08

KW-0378

Hydrolase

5 of 451

1.19

1.06

0.00067

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00561

Alpha/beta hydrolase fold

7 of 27

2.56

6.61

5.36e-14

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006693

Partial AB-hydrolase lipase domain

5 of 5

3.14

5.75

2.75e-11

IPR025483

Lipase, eukaryotic

4 of 4

3.14

4.36

1.12e-08

IPR029058

Alpha/Beta hydrolase fold

9 of 244

1.71

3.58

1.40e-11

IPR000073

Alpha/beta hydrolase fold-1

4 of 45

2.09

2.29

2.50e-05

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