L1IC19_GUITC protein (Guillardia theta) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

L1IC19_GUITC

Uncharacterized protein; Belongs to the AAA ATPase family. (655 aa)

Predicted Functional Partners:

L1JRX7_GUITC

0.962

L1IWW5_GUITC

0.928

L1JWP0_GUITC

0.923

L1J3J5_GUITC

0.916

L1JIJ9_GUITC

0.916

L1J2L9_GUITC

0.872

L1JBP0_GUITC

0.862

L1JG11_GUITC

0.831

L1JWV3_GUITC

0.831

L1JSI9_GUITC

0.795

Your Current Organism:

Guillardia theta

NCBI taxonomy Id: 905079
Other names: G. theta CCMP2712, Guillardia theta CCMP2712

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L1IC19_GUITC	L1IWW5_GUITC	L1IC19	L1IWW5	Uncharacterized protein; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.928
L1IC19_GUITC	L1J2L9_GUITC	L1IC19	L1J2L9	Uncharacterized protein; Belongs to the AAA ATPase family.	WD_REPEATS_REGION domain-containing protein.	0.872
L1IC19_GUITC	L1J3J5_GUITC	L1IC19	L1J3J5	Uncharacterized protein; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.916
L1IC19_GUITC	L1JBP0_GUITC	L1IC19	L1JBP0	Uncharacterized protein; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.862
L1IC19_GUITC	L1JG11_GUITC	L1IC19	L1JG11	Uncharacterized protein; Belongs to the AAA ATPase family.	WD_REPEATS_REGION domain-containing protein.	0.831
L1IC19_GUITC	L1JIJ9_GUITC	L1IC19	L1JIJ9	Uncharacterized protein; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.916
L1IC19_GUITC	L1JRX7_GUITC	L1IC19	L1JRX7	Uncharacterized protein; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.962
L1IC19_GUITC	L1JSI9_GUITC	L1IC19	L1JSI9	Uncharacterized protein; Belongs to the AAA ATPase family.	RRM domain-containing protein.	0.795
L1IC19_GUITC	L1JWP0_GUITC	L1IC19	L1JWP0	Uncharacterized protein; Belongs to the AAA ATPase family.	MI domain-containing protein.	0.923
L1IC19_GUITC	L1JWV3_GUITC	L1IC19	L1JWV3	Uncharacterized protein; Belongs to the AAA ATPase family.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	0.831
L1IWW5_GUITC	L1IC19_GUITC	L1IWW5	L1IC19	Uncharacterized protein.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.928
L1IWW5_GUITC	L1J2L9_GUITC	L1IWW5	L1J2L9	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.980
L1IWW5_GUITC	L1J3J5_GUITC	L1IWW5	L1J3J5	Uncharacterized protein.	Uncharacterized protein.	0.653
L1IWW5_GUITC	L1JBP0_GUITC	L1IWW5	L1JBP0	Uncharacterized protein.	Uncharacterized protein.	0.833
L1IWW5_GUITC	L1JG11_GUITC	L1IWW5	L1JG11	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.977
L1IWW5_GUITC	L1JIJ9_GUITC	L1IWW5	L1JIJ9	Uncharacterized protein.	Uncharacterized protein.	0.653
L1IWW5_GUITC	L1JRX7_GUITC	L1IWW5	L1JRX7	Uncharacterized protein.	Uncharacterized protein.	0.949
L1IWW5_GUITC	L1JSI9_GUITC	L1IWW5	L1JSI9	Uncharacterized protein.	RRM domain-containing protein.	0.841
L1IWW5_GUITC	L1JWP0_GUITC	L1IWW5	L1JWP0	Uncharacterized protein.	MI domain-containing protein.	0.709
L1IWW5_GUITC	L1JWV3_GUITC	L1IWW5	L1JWV3	Uncharacterized protein.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	0.952

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.841

expected number of edges:

16

PPI enrichment p-value:

3.86e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

8 of 82

1.26

1.64

5.36e-07

GO:0007165

Signal transduction

9 of 122

1.14

1.4

5.36e-07

GO:0019538

Protein metabolic process

8 of 194

0.88

0.84

5.34e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

7 of 39

1.52

2.26

1.94e-07

GO:0000155

Phosphorelay sensor kinase activity

6 of 35

1.5

2.0

2.21e-06

GO:0140096

Catalytic activity, acting on a protein

9 of 109

1.19

1.54

1.80e-07

GO:0016740

Transferase activity

8 of 304

0.69

0.54

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2313

Phosphorelay signal transduction system, and GGDEF domain

6 of 72

1.19

1.17

0.00018

CL:2397

PAC motif, and Putative diguanylate phosphodiesterase

3 of 12

1.67

1.17

0.0034

CL:2309

Signal transduction, and Flagellar assembly

8 of 171

0.94

0.87

0.00018

CL:2400

Mixed, incl. PAS domain, and SsuA/THI5-like

2 of 6

1.79

0.78

0.0310

CL:2317

Phosphorelay signal transduction system

3 of 29

1.28

0.7

0.0250

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

5 of 58

1.2

0.98

0.0019

KW-0597

Phosphoprotein

5 of 63

1.17

0.95

0.0019

KW-0175

Coiled coil

7 of 254

0.71

0.51

0.0070

KW-0808

Transferase

6 of 237

0.67

0.4

0.0359

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 29

1.65

2.73

2.51e-08

IPR003594

Histidine kinase/HSP90-like ATPase

8 of 40

1.57

2.65

6.63e-09

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

8 of 41

1.56

2.62

6.63e-09

IPR005467

Histidine kinase domain

7 of 37

1.55

2.38

8.52e-08

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

6 of 35

1.5

1.96

3.24e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

8 of 39

1.58

2.89

4.69e-10

SM00388

His Kinase A (phosphoacceptor) domain

5 of 35

1.42

1.61

3.40e-05

SM00448

cheY-homologous receiver domain

5 of 55

1.23

1.21

0.00018

SM00091

PAS domain

3 of 21

1.42

1.03

0.0040

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 21

1.42

1.03

0.0040

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