L1IG40_GUITC protein (Guillardia theta) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

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gene co-occurrence

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Score

L1IG40_GUITC

Importin N-terminal domain-containing protein. (1111 aa)

Predicted Functional Partners:

L1IDK5_GUITC

0.874

L1JF34_GUITC

0.874

L1J4G6_GUITC

0.831

L1JQZ2_GUITC

0.831

L1IB42_GUITC

0.792

L1I6B2_GUITC

0.686

L1IU02_GUITC

0.686

L1JDW7_GUITC

0.651

L1J117_GUITC

0.637

L1IS54_GUITC

0.622

Your Current Organism:

Guillardia theta

NCBI taxonomy Id: 905079
Other names: G. theta CCMP2712, Guillardia theta CCMP2712

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L1I6B2_GUITC	L1IB42_GUITC	L1I6B2	L1IB42	Histone H2A; Belongs to the histone H2A family.	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.752
L1I6B2_GUITC	L1IDK5_GUITC	L1I6B2	L1IDK5	Histone H2A; Belongs to the histone H2A family.	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family.	0.876
L1I6B2_GUITC	L1IG40_GUITC	L1I6B2	L1IG40	Histone H2A; Belongs to the histone H2A family.	Importin N-terminal domain-containing protein.	0.686
L1I6B2_GUITC	L1IS54_GUITC	L1I6B2	L1IS54	Histone H2A; Belongs to the histone H2A family.	Histone H2A; Belongs to the histone H2A family.	0.834
L1I6B2_GUITC	L1J4G6_GUITC	L1I6B2	L1J4G6	Histone H2A; Belongs to the histone H2A family.	Histone H2B; Belongs to the histone H2B family.	0.945
L1I6B2_GUITC	L1JF34_GUITC	L1I6B2	L1JF34	Histone H2A; Belongs to the histone H2A family.	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family.	0.876
L1I6B2_GUITC	L1JQZ2_GUITC	L1I6B2	L1JQZ2	Histone H2A; Belongs to the histone H2A family.	Histone H2B; Belongs to the histone H2B family.	0.945
L1IB42_GUITC	L1I6B2_GUITC	L1IB42	L1I6B2	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Histone H2A; Belongs to the histone H2A family.	0.752
L1IB42_GUITC	L1IG40_GUITC	L1IB42	L1IG40	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Importin N-terminal domain-containing protein.	0.792
L1IB42_GUITC	L1IS54_GUITC	L1IB42	L1IS54	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Histone H2A; Belongs to the histone H2A family.	0.471
L1IB42_GUITC	L1IU02_GUITC	L1IB42	L1IU02	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Histone H2A; Belongs to the histone H2A family.	0.752
L1IB42_GUITC	L1J117_GUITC	L1IB42	L1J117	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Importin N-terminal domain-containing protein.	0.998
L1IB42_GUITC	L1J4G6_GUITC	L1IB42	L1J4G6	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Histone H2B; Belongs to the histone H2B family.	0.594
L1IB42_GUITC	L1JDW7_GUITC	L1IB42	L1JDW7	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Importin N-terminal domain-containing protein.	0.984
L1IB42_GUITC	L1JQZ2_GUITC	L1IB42	L1JQZ2	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Histone H2B; Belongs to the histone H2B family.	0.594
L1IDK5_GUITC	L1I6B2_GUITC	L1IDK5	L1I6B2	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family.	Histone H2A; Belongs to the histone H2A family.	0.876
L1IDK5_GUITC	L1IG40_GUITC	L1IDK5	L1IG40	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family.	Importin N-terminal domain-containing protein.	0.874
L1IDK5_GUITC	L1IS54_GUITC	L1IDK5	L1IS54	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family.	Histone H2A; Belongs to the histone H2A family.	0.679
L1IDK5_GUITC	L1IU02_GUITC	L1IDK5	L1IU02	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family.	Histone H2A; Belongs to the histone H2A family.	0.876
L1IDK5_GUITC	L1J4G6_GUITC	L1IDK5	L1J4G6	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family.	Histone H2B; Belongs to the histone H2B family.	0.751

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.788

expected number of edges:

11

PPI enrichment p-value:

2.85e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042558

Pteridine-containing compound metabolic process

3 of 10

1.68

1.2

0.0031

GO:0006431

methionyl-tRNA aminoacylation

2 of 2

2.21

1.09

0.0092

GO:0006520

Cellular amino acid metabolic process

6 of 86

1.05

0.94

0.00052

GO:0009086

Methionine biosynthetic process

2 of 5

1.81

0.89

0.0185

GO:0016070

RNA metabolic process

6 of 98

0.99

0.84

0.00098

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004825

methionine-tRNA ligase activity

2 of 2

2.21

0.82

0.0309

GO:0016741

Transferase activity, transferring one-carbon groups

4 of 34

1.28

0.71

0.0235

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

2 of 4

1.91

0.7

0.0473

GO:0016646

Oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

2 of 6

1.73

0.68

0.0474

GO:0140101

Catalytic activity, acting on a tRNA

4 of 43

1.17

0.65

0.0276

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

7 of 178

0.8

0.63

0.0021

GO:0005622

Intracellular anatomical structure

11 of 747

0.37

0.31

0.0031

GO:0005737

Cytoplasm

10 of 672

0.38

0.3

0.0120

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:362

16S rRNA methyltransferase RsmB/F, and Formyl transferase

4 of 5

2.11

2.22

3.83e-05

CL:291

tRNA aminoacylation

3 of 13

1.57

1.03

0.0061

CL:79

Translation, and RNA biosynthetic process

7 of 147

0.88

0.71

0.0015

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cgo00670

One carbon pool by folate

5 of 9

1.95

2.85

5.07e-07

cgo00450

Selenocompound metabolism

3 of 6

1.91

1.59

0.00060

cgo00970

Aminoacyl-tRNA biosynthesis

4 of 27

1.38

1.24

0.00063

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0648

Protein biosynthesis

5 of 41

1.29

1.17

0.00060

KW-0030

Aminoacyl-tRNA synthetase

3 of 23

1.32

0.67

0.0333

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