L1IXM7_GUITC protein (Guillardia theta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

L1IXM7_GUITC

Uncharacterized protein. (332 aa)

Predicted Functional Partners:

L1JNY1_GUITC

0.880

L1JV34_GUITC

0.782

L1IHD0_GUITC

0.739

L1IVM2_GUITC

0.739

L1J3J1_GUITC

0.739

L1IFR0_GUITC

0.509

L1IFG7_GUITC

0.466

L1IIW8_GUITC

0.466

L1J550_GUITC

0.466

L1JMM1_GUITC

0.466

Your Current Organism:

Guillardia theta

NCBI taxonomy Id: 905079
Other names: G. theta CCMP2712, Guillardia theta CCMP2712

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L1IFG7_GUITC	L1IFR0_GUITC	L1IFG7	L1IFR0	Histone H3 variant.	Bromo domain-containing protein.	0.416
L1IFG7_GUITC	L1IHD0_GUITC	L1IFG7	L1IHD0	Histone H3 variant.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.637
L1IFG7_GUITC	L1IVM2_GUITC	L1IFG7	L1IVM2	Histone H3 variant.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.726
L1IFG7_GUITC	L1IXM7_GUITC	L1IFG7	L1IXM7	Histone H3 variant.	Uncharacterized protein.	0.466
L1IFG7_GUITC	L1J3J1_GUITC	L1IFG7	L1J3J1	Histone H3 variant.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.723
L1IFG7_GUITC	L1JNY1_GUITC	L1IFG7	L1JNY1	Histone H3 variant.	Uncharacterized protein.	0.638
L1IFG7_GUITC	L1JV34_GUITC	L1IFG7	L1JV34	Histone H3 variant.	ING domain-containing protein.	0.738
L1IFR0_GUITC	L1IFG7_GUITC	L1IFR0	L1IFG7	Bromo domain-containing protein.	Histone H3 variant.	0.416
L1IFR0_GUITC	L1IHD0_GUITC	L1IFR0	L1IHD0	Bromo domain-containing protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.505
L1IFR0_GUITC	L1IIW8_GUITC	L1IFR0	L1IIW8	Bromo domain-containing protein.	Histone H3 variant.	0.416
L1IFR0_GUITC	L1IVM2_GUITC	L1IFR0	L1IVM2	Bromo domain-containing protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.505
L1IFR0_GUITC	L1IXM7_GUITC	L1IFR0	L1IXM7	Bromo domain-containing protein.	Uncharacterized protein.	0.509
L1IFR0_GUITC	L1J3J1_GUITC	L1IFR0	L1J3J1	Bromo domain-containing protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.505
L1IFR0_GUITC	L1J550_GUITC	L1IFR0	L1J550	Bromo domain-containing protein.	Histone H3; Belongs to the histone H3 family.	0.416
L1IFR0_GUITC	L1JMM1_GUITC	L1IFR0	L1JMM1	Bromo domain-containing protein.	Histone H3.	0.416
L1IFR0_GUITC	L1JNY1_GUITC	L1IFR0	L1JNY1	Bromo domain-containing protein.	Uncharacterized protein.	0.646
L1IFR0_GUITC	L1JV34_GUITC	L1IFR0	L1JV34	Bromo domain-containing protein.	ING domain-containing protein.	0.647
L1IHD0_GUITC	L1IFG7_GUITC	L1IHD0	L1IFG7	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Histone H3 variant.	0.637
L1IHD0_GUITC	L1IFR0_GUITC	L1IHD0	L1IFR0	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Bromo domain-containing protein.	0.505
L1IHD0_GUITC	L1IIW8_GUITC	L1IHD0	L1IIW8	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Histone H3 variant.	0.637

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.853

expected number of edges:

11

PPI enrichment p-value:

0.000307

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000819

Sister chromatid segregation

10 of 19

2.5

9.23

1.09e-20

GO:0007062

Sister chromatid cohesion

7 of 11

2.58

6.74

3.44e-14

GO:0022402

Cell cycle process

11 of 83

1.9

5.74

1.42e-18

GO:0000070

Mitotic sister chromatid segregation

6 of 13

2.44

5.27

2.32e-11

GO:0000280

Nuclear division

7 of 33

2.1

4.74

1.33e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003682

Chromatin binding

5 of 35

1.93

2.54

3.02e-06

GO:0005488

Binding

11 of 2634

0.4

0.29

0.0222

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044815

DNA packaging complex

8 of 28

2.23

5.99

3.09e-14

GO:0008278

Cohesin complex

5 of 5

2.78

5.24

1.25e-10

GO:0005694

Chromosome

10 of 133

1.65

3.78

4.99e-14

GO:0000796

Condensin complex

3 of 4

2.65

2.67

1.13e-05

GO:0043232

Intracellular non-membrane-bounded organelle

11 of 494

1.13

1.62

8.78e-11

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4007

Sister chromatid segregation

10 of 13

2.66

10.43

2.88e-22

CL:4010

Establishment of Sister Chromatid Cohesion

6 of 6

2.78

6.42

5.26e-13

CL:4023

Chromosome condensation

3 of 5

2.56

2.48

2.39e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2468052

Establishment of Sister Chromatid Cohesion

7 of 8

2.72

7.25

7.27e-15

MAP-68884

Mitotic Telophase/Cytokinesis

6 of 6

2.78

6.3

9.20e-13

MAP-2470946

Cohesin Loading onto Chromatin

6 of 6

2.78

6.3

9.20e-13

MAP-68877

Mitotic Prometaphase

9 of 47

2.06

5.68

4.67e-15

MAP-2500257

Resolution of Sister Chromatid Cohesion

6 of 31

2.07

4.03

8.54e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008278

Cohesin complex

5 of 5

2.78

5.22

1.38e-10

GOCC:0000793

Condensed chromosome

7 of 24

2.24

5.21

4.89e-12

GOCC:0005694

Chromosome

9 of 137

1.6

3.21

9.44e-12

GOCC:0043232

Intracellular non-membrane-bounded organelle

11 of 384

1.24

1.98

9.44e-12

GOCC:0000796

Condensin complex

2 of 4

2.48

1.38

0.0029

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13304

AAA domain, putative AbiEii toxin, Type IV TA system

2 of 3

2.6

1.05

0.0124

PF04825

N terminus of Rad21 / Rec8 like protein

2 of 2

2.78

1.05

0.0124

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039781

Rad21/Rec8-like protein

2 of 2

2.78

0.89

0.0247

IPR006910

Rad21/Rec8-like protein, N-terminal

2 of 2

2.78

0.89

0.0247

IPR036277

SMCs flexible hinge superfamily

2 of 4

2.48

0.88

0.0247

IPR024704

Structural maintenance of chromosomes protein

2 of 4

2.48

0.88

0.0247

IPR010935

SMCs flexible hinge

2 of 4

2.48

0.88

0.0247

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00968

SMC proteins Flexible Hinge Domain

2 of 4

2.48

1.1

0.0095

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About