L1IZQ4_GUITC protein (Guillardia theta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

L1IZQ4_GUITC

Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (164 aa)

Predicted Functional Partners:

L1IP79_GUITC

0.999

L1IXZ8_GUITC

0.998

L1IIL6_GUITC

0.983

L1IT20_GUITC

0.977

L1IPG2_GUITC

0.976

L1J2C8_GUITC

0.975

L1IKQ1_GUITC

0.969

L1K1P8_GUITC

0.969

L1IUE6_GUITC

0.966

L1J3J6_GUITC

0.966

Your Current Organism:

Guillardia theta

NCBI taxonomy Id: 905079
Other names: G. theta CCMP2712, Guillardia theta CCMP2712

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L1IIL6_GUITC	L1IP79_GUITC	L1IIL6	L1IP79	GCV_T domain-containing protein.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.887
L1IIL6_GUITC	L1IPG2_GUITC	L1IIL6	L1IPG2	GCV_T domain-containing protein.	Uncharacterized protein; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.469
L1IIL6_GUITC	L1IT20_GUITC	L1IIL6	L1IT20	GCV_T domain-containing protein.	Uncharacterized protein.	0.469
L1IIL6_GUITC	L1IUE6_GUITC	L1IIL6	L1IUE6	GCV_T domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.626
L1IIL6_GUITC	L1IZQ4_GUITC	L1IIL6	L1IZQ4	GCV_T domain-containing protein.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.983
L1IIL6_GUITC	L1J2C8_GUITC	L1IIL6	L1J2C8	GCV_T domain-containing protein.	Dihydrolipoyl dehydrogenase.	0.469
L1IIL6_GUITC	L1J3J6_GUITC	L1IIL6	L1J3J6	GCV_T domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.626
L1IKQ1_GUITC	L1IP79_GUITC	L1IKQ1	L1IP79	Uncharacterized protein.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.852
L1IKQ1_GUITC	L1IPG2_GUITC	L1IKQ1	L1IPG2	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.520
L1IKQ1_GUITC	L1IT20_GUITC	L1IKQ1	L1IT20	Uncharacterized protein.	Uncharacterized protein.	0.520
L1IKQ1_GUITC	L1IUE6_GUITC	L1IKQ1	L1IUE6	Uncharacterized protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.585
L1IKQ1_GUITC	L1IZQ4_GUITC	L1IKQ1	L1IZQ4	Uncharacterized protein.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.969
L1IKQ1_GUITC	L1J2C8_GUITC	L1IKQ1	L1J2C8	Uncharacterized protein.	Dihydrolipoyl dehydrogenase.	0.520
L1IKQ1_GUITC	L1J3J6_GUITC	L1IKQ1	L1J3J6	Uncharacterized protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.585
L1IP79_GUITC	L1IIL6_GUITC	L1IP79	L1IIL6	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	GCV_T domain-containing protein.	0.887
L1IP79_GUITC	L1IKQ1_GUITC	L1IP79	L1IKQ1	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Uncharacterized protein.	0.852
L1IP79_GUITC	L1IPG2_GUITC	L1IP79	L1IPG2	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Uncharacterized protein; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.934
L1IP79_GUITC	L1IT20_GUITC	L1IP79	L1IT20	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Uncharacterized protein.	0.934
L1IP79_GUITC	L1IUE6_GUITC	L1IP79	L1IUE6	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.978
L1IP79_GUITC	L1IXZ8_GUITC	L1IP79	L1IXZ8	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.999

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.836

expected number of edges:

13

PPI enrichment p-value:

0.0148

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010498

Proteasomal protein catabolic process

11 of 152

2.0

6.44

3.47e-19

GO:0006511

Ubiquitin-dependent protein catabolic process

7 of 230

1.63

2.71

1.69e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004298

Threonine-type endopeptidase activity

2 of 3

2.97

1.23

0.0059

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005839

Proteasome core complex

11 of 14

3.04

14.89

1.04e-29

GO:0019773

Proteasome core complex, alpha-subunit complex

6 of 7

3.08

7.69

4.75e-15

GO:0019774

Proteasome core complex, beta-subunit complex

5 of 7

3.0

6.12

4.21e-12

GO:0005634

Nucleus

11 of 2154

0.85

0.94

2.80e-08

GO:0005737

Cytoplasm

11 of 5000

0.49

0.42

0.00022

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3435

Cross-presentation of soluble exogenous antigens (endosomes)

11 of 29

2.72

12.39

1.87e-26

CL:3467

Proteasome core complex

7 of 10

2.99

8.67

4.03e-17

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03050

Proteasome

11 of 42

2.56

11.56

3.67e-26

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-187577

SCF(Skp2)-mediated degradation of p27/p21

10 of 35

2.6

10.62

2.84e-23

MAP-1236978

Cross-presentation of soluble exogenous antigens (endosomes)

10 of 36

2.59

10.56

3.03e-23

MAP-1236975

Antigen processing-Cross presentation

10 of 37

2.58

10.5

3.29e-23

MAP-174178

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

11 of 54

2.45

10.35

2.60e-24

MAP-9755511

KEAP1-NFE2L2 pathway

11 of 57

2.43

10.23

2.60e-24

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005839

Proteasome core complex

11 of 14

3.04

14.83

1.37e-29

GOCC:0019773

Proteasome core complex, alpha-subunit complex

6 of 7

3.08

7.59

7.49e-15

GOCC:0019774

Proteasome core complex, beta-subunit complex

5 of 7

3.0

6.03

6.31e-12

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0888

Threonine protease

9 of 11

3.06

11.94

1.59e-23

KW-0647

Proteasome

8 of 11

3.01

10.36

1.83e-20

KW-0963

Cytoplasm

9 of 122

2.01

5.73

5.51e-16

KW-0539

Nucleus

9 of 297

1.63

3.47

1.05e-12

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00227

Proteasome subunit

11 of 15

3.01

14.56

3.35e-29

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001353

Proteasome, subunit alpha/beta

11 of 15

3.01

14.36

9.30e-29

IPR029055

Nucleophile aminohydrolases, N-terminal

11 of 23

2.82

13.2

1.72e-27

IPR023332

Proteasome alpha-type subunit

6 of 7

3.08

7.17

4.88e-14

IPR000426

Proteasome alpha-subunit, N-terminal domain

6 of 7

3.08

7.17

4.88e-14

IPR023333

Proteasome B-type subunit

5 of 8

2.94

5.51

5.62e-11

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00948

Proteasome subunit A N-terminal signature Add an annotation

6 of 7

3.08

7.43

1.53e-14

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About